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- 要約等...histication of advances in medicine in the past two d......ssitated a growing need for a co......current issues in medicine. Each volume in the Current Issues in Medicine series is a s......l accomplished in a user-friendly yet interconnected fo......lights current advances but also explo......slational medicine, regulatory s......ta, artificial intelligence, novel imaging tools, combination drug prod......es. While bridging the gap betwe......research, medicine, engineering, FDA law, intellectual prop......ough understanding of medicine's potential t......s perspectives in a healthcare setting. The range of topics covered...
- 内容細目... Modifications Influence Protein Aggregation in Neurodegenerat......ayne G. Carter DNA Damage/Repair Management in Cancers Jehad ......oolley, Ala-Eddin Al Moustafa, a......ad Malki Advancing Clinical Cohort Sel...... M. Smith, Melvin Lathara, Holli......Brian Hill, Nalini Ganapati, Ganapati Srinivasa, Christop...... Formulation Principle to Improv......Olga Pelikh, Rainer H. Mller, an......rds Biomimicry in Theranostics M......onathan O. Martinez, IDand Ennio......ures Selection in the Classifica......sponse Control in the Children a......lular Vesicles Involved in Intercellular Com......lcieri Circulating Tumor Cells and Personalized...
- 件名Clinical biochemistry Biochimie clinique SCIENCE--Life Sciences--General. Clinical biochemistry.
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- 要約等...enetic changes in prostate cells......at are the driving forces in the initiation and pr....... Surveys cell interactions, including stem cells, reactive Stromal...
- 内容細目Diet and lifestyle in prostate cance......ci Dietary carcinogens and DNA adducts in prostate cance...... factors governing genomic rearr......i Cells of origin for prostate cancer / Li Xin Prostate cance......croenvironment influences the re......croenvironment in prostate cance......sis / Anthony DiNatale and Aless......sis / Chenchu Lin [and 11 others......ivity / Karl-Heinz Storbeck Germline and somatic defects in DNA repair pathways in prostate cance......ndro Athie, Colin C. Pritchard, and Joaquin Matco The role of RB in prostate cance......[and 4 others] Interplay among P......O and AR signaling in prostate cancer / Yuqian ...
- 一般注記Originally published ......(New York : Springer, ©2013)
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- 内容細目...ry, thanks to wine and science M......Stem cells and DNA repair capacity Tizia...... Muse cells Administration in Diabetes Marce......e mitochondria in the evolution of stem cells, including Muse stem cel......ute myocardial infarction, cardi......d Muse cells Shinya Minatoguchi ほか著 Ap......ngan, Teiji Tominaga 著 Muse cell......ve homeostasis in ischemic strok......ased therapies in the chronic li......ses Taketo Nishina, Kyoko Tomita......mented human skin created by Mus......perfusion lung injury Hiroshi Yabuki ほか著 Clinical trials of Muse cells Futu...
- 関連情報Advances in experimental medicine and biology
- 掲載誌Advances in experimental medicine and biology
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- 内容細目...Estrogen Signaling Pathways and DNA Repair Machinery; Abstract; Introduction; Mil...... the Route Leading to the Recogn......Hormonal Signaling and Genomic S......ed Differences in the Prevalence......rmal Mechanism in Cancer Risk; Increased Female ......ve Cancer Risk in Northen Geogra......hic Regions Is in Correlation wi......Estrogen Signaling Induces Insulin Resistance and......Estrogen Signaling Pathways and DNA Repair Machinery; Mutual Upr......Receptor Signaling and DNA Controlling Activity of BRCA-Protein; Estrogen Signaling Promotes the ......ssor p53 Gene; Interplay between......Estrogen Signaling and PTEN during Cell Prolife...
- 件名Carcinogenesis. HEALT......al MEDICAL / Clinical Medicine MEDICAL / Dis......nce-Based Medicine MEDICAL / Internal Medicine
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- 要約等...rstand and examine dynamic processes of infection at the ......lar level. Cutting-edge research......opics such as single-molecule observation of DNA replication repair pathways in E. coli; evolu......rug resistance in bacteria; rest...... gene transfer in Staphylococcus aureus; infectious and ba...... biofilms; killing infectious pathogens through DNA damage; bacterial surfaces in host-pathogen interactions; bac......ion regulation in enterobacteria......agellar motor; initial surface c......well as monitoring proton motive force in bacteria; micr......al pathogens using digital holog......ematical modelling of microbial pathogen motili...
- 内容細目...ston, Jodi A. Lindsay and David ......al analysis of infectious biofil......vid Head Designing a single-molecule bi......for characterising DNA damage for tec......ques that kill infectious pathogens through DNA damage effects......rfaces: front lines in host-pathogen interaction / Jane E. King and Ian S. Ro......nathan P. Grondin, Daniel A. Lafontaine and J. Carlos......Dmitri O. Pushkin and Martin A. Bees Transc......ess management in enterobacteria...... Zhang and Martin Buck How bioph......ia which cause infections / Matt......rial cells and initial surface c......r, Laura E. McKinley and Simon T......tefania Spanò Insights into biological complex...
- 件名Infection. Biophysics. Bacterial Infections--microbiology. Bacter...
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- 内容細目...Sarathi and Nalini S. Shah Amyot......a and hypoalbuminemia/ataxia wit......... [et al.] Clinical features a......er's disease : involvement of mi...... mitochondrial DNA / Michelangelo....... [et al.] Huntington's disease ......... [et al.] Clinical features a......echanisms of spinal and bulbar m......... [et al.] Spinocerebellar ata......is complex and DNA repair / Samy L. Habi......ge syndrome / Jinglan Liu and Ga......chemoradiation in the treatment ......rew R. Gennery Inherited defects......of immunoglobulin class switch recombination / Sven Kracker, Pauline Gardës and An...... Carlos H. Martínez, Sumit Dave and Jonathan Iz...
- 件名DNA repair. Genetic disor......etic Diseases, Inborn -- etiology. DNA Repair -- physiology.......etic Diseases, Inborn -- therapy.
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- 内容細目Progress in somatic hyperm......search / Hong Ming Shen Factors leading to the induction and conversion of DNA damage into structural c......genetic damage inducers / Carla ......and Olga Mayan DNA damage related......rites : dissecting the mechanisms of discrimination in DNA repair / Thierry P. N......pro-apoptotic kinases on nuclear targeting and induction of apoptosis in response to DNA damage / Kiyot......ive stress and DNA damage checkpoints in early cancer? ......ignificance of DNA damage checkpoint and the mode of checkpoint signal amplif......atment suppressing mitochondrial DNA damage caused ......r basis of guanine oxidation under UV-A/VIS rad...
- 件名DNA damage. DNA Damage -- physiology. Apoptosis -- genetics. DNA Repair -- physiology.
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- 内容細目...otide excision repair / James E. Cleaver Clinical features o......mentosum and skin cancer / Leela......nscription and DNA repair / Brian D. Bec......mad Other proteins interacting with XP proteins / Steven M. S......otide excision repair of DNA in human cells an......idative stress in xeroderma pigm......m therapy / Alain Sarasin Animal models of xeroderma pi...
- 件名...cular aspects. DNA repair. Xeroderma Pig......m -- genetics. DNA Repair Enzymes -- genetics. DNA Repair-Deficiency Disorders -- genet...
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- 内容細目The problem of genome instability. The ......y of mutations in human cancers ....... Loeb. Monitoring chromosome re......el R. Speicher DNA repair and mutagenesi......otide excision repair and its connec...... cancer and ageing / Jaan-Olle A......Harm de Waard. DNA mismatch repair and colon canc...... Base excision repair / Lisiane B. M......amson. Genomic instability in cancer develop......erases / Catherine M. Green and ......berration. The INK4A/ARF network......l cycle checkpoint or emergency ......Gordon Peters. DNA replication and genomic instability / Wen......ek Abbas and Anindya Dutta. The ......tural dynamics in genome integrity control and ...
- 件名...ology. Genomic Instability. Mutation. DNA Repair.
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- 件名DNA repair Antimutagens -- Therapeutic u...
- 件名（識別子）DNA repair Antimutagens -- Therapeutic u...
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- 内容細目Sunlight, UV-radiation, vitamin D and skin cancer: how mu......nce and cancer incidence and mor...... B. Grant Vitamin D status and cancer incidence and mor......ancer survival in Norway: changes in the risk of de......d latitude / Alina Carmen Porojn......5-hydroxy vitamin D levels for m......cutaneous vitamin D synthesis / ......uld one go out in the sun? / Joh......Dahlback and Alina Carmen Porojn...... nonmelanoma skin cancer--the ro...... Johan Moan, Alina Carmen Porojn......rtality from skin tumors / Maria......et al.] Health initiatives for t......revention of skin cancer / Rüdiger Greinert ... [et al.] Sunscreens / ...
- 件名Skin -- Cancer. Sunshine. Vitamin D -- Therapeutic use. Skin Neoplasms -- p......Sunlight. Vitamin D -- therapeutic use.
Charged particle and photon interactions with matter : recent advances, applications, and interfaces
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- 内容細目Ch. 1. Introduction / Yo......n of molecules in the gas phase in the vacuum ult......d dynamics of singly inner-valence exc......with molecules in the gas phase ......New directions in W-value studie......n annihilation in radiation chem......de ch. 8. Muon interactions with......ation and trapping in hydrocarbon li......adical cations in nonpolar conde......d matter / Ortwin Brede and Serg......ous chemistr y induced by ionizing radiation with low linear energy transfer in water and pola......temperature / Vincent De Waele, ......is studies / Shinichi Tamashita ......ion studies / Jintana Messungnoe......an-Paul Jay-Gerin ch. 15. Radiation chemistry o...
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- 参照Expression of DNA damage response proteins in gastric cancer......rehensive protein profiling and histological analysis
- 並列タイトル等（連結）DNA damage repair in gastric cancer
- 並列タイトル等DNA damage repair in gastric cancer
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- 参照Multiplex genotyping method to val......lic genome editing outcomes using machine learning-assisted long-read sequencing Speciation an......ets genome editing Efficient biallelic knock-in in mouse embryoni...... stem cells by in vivo-linearization of d...... and transient inhibition of DNA polymerase θ/DNA-PK DAJIN enables multiplex genotyping to simultaneously validate intended and unintended target genome editing outcomes Deve......na for visualizing homology-directed repair of DNA Characterizati......oxn1 mutations induced in rat embryos by...... Epigenome Editing-Based Therape......ges Genome editing is induced in a binary manne...
- 出版者（掲載誌）Springer Science and Business Media LLC
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- 要約等...ere we show, using whole-exome a...... genome sequencing within a precision on......nomic patterns indicative of def......mologous recombination (HR) DNA repair and alterations affecting HR-related genes, including, for example,......athogenic germline variants of <......antly enriched in 72.7% of sampl......d with genomic instability. The ......ymerase (PARP) inhibitor olapari......ly toxic to HR-incompetent cells......to prolonged clinical benefit in a patient with......isrupt the autoinhibitory PARP1 helical domain. These findings uncover a th......ic opportunity in chordoma that ......n, and provide insight into the mechanisms unde...
- 件名...ry Multidisciplinary
- 参照Genetic Testing Distinguishes Multiple Chondroid Cho...
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- 要約等...tients receive DNA-damaging drugs or ionizing radiation (IR) during their course ......is tempered by DNA repair and DNA damage respons......s. Aberrations in DNA repair and the DDR are observed in many cancer su......ats:italic>carcinogenesis, genomic instability, and ensuing resistance to......d or collapsed DNA replication fo...... double-strand DNA break (DSB) repair system. Of the various inducible DNA lesions, DSBs ......thus desirable in the setting of cancer treatment. In mammalian cell...... are typically repaired by the error......mologous end joining pathway (NHEJ......ology directed repair (HDR) pathway. Targeting DSB ...
- 参照...egy for Evaluating the Natural Antioxidant-Induced Double-Stranded DNA Break (DSB) Style
- 著者標目.... Pandey Katherine S. Pawelczak John J. Turchi ...
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- 要約等...ymerase (PARP) inhibitors have e......erged as promising therapy in cancers with h......mologous recombination repair deficiency. Ho......imited by both intrinsic and acquire......e Olaparib Combinations basket t......arib alone and in combination with othe......mologous recombination–directed ......lts of the arm in which olaparib was combined with the ora......d RAD3-related inhibitor ceralasertib in patients with ...... cancers harboring DNA damage response and repair alterations, including patients with......A-mutated PARP inhibitor–resista......><jats:p> Germline and somatic m......by COSMIC or ClinVar for eligibility. Olaparib ...
- 参照Emerging strategies fo......<scp>ATR</scp> inhibitors First phase 1 clinical study of olaparib in pediatric pati......solid tumors Clinical Landscape of PARP Inhibitors in Ovarian Cancer: Molecular Mec...
- 著者標目...ffrey Sklar Colin Glover Brunella Felicetti Emm...
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- 件名General Medicine
- 参照Carboplatin in BRCA1/2-mutate......es to Carboplatin Indicating Different Types of DNA Repair Deficiency BRC......ther DDR Genes in Prostate Cancer Preliminary results fro......y of rucaparib in patients (pts) with DNA damage repair (DDR)-deficien...... analyses Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors Multinational, Double-Blind, Phase III St......ither Satraplatin or Placebo in Patients With ......Cancer Progressing After Prior C......SPARC Trial PROREPAIR-B: A Prospecti......Impact of Germline DNA Repair Mutations on t......2019 Biallelic Inactivation of BRCA2 in Platinum-sensitive Me......rostate Cancer DNA-Repair Defects and Olaparib i...
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- 参照Survival with Olaparib in Metastatic Cas......r Detection of intraductal carcinoma in prostate cancer patients with...