検索結果 3 件
記事
全国の図書館
- 要約等Several chemotherapeutic drugs have immune-modulating effects. For example, cyclophosphamide (CP) and gemcitabine (GEM) diminish immunosuppr......ssion by regulatory T cells (Tregs) and myelo......ved suppressor cells (MDSCs), respectively. Here, we show that intermittent (metronomic) chemotherapy with low-dose CP plus GEM can induce anti-tumor T cell immunity in CT26 colon carcinoma-bearing mice. Although no significant growth suppression was observed by injections of CP (100 mg/kg) at 8-day intervals or those of CP (50 mg/kg) at 4-day intervals, CP injection (100 mg/kg) increased the frequency of tumor peptide-specific T lympho...
- 件名Cyclophosphamide Gemcitabine T cell immunity MDSC Treg
- 著者標目Tongu, Miki Hara......onma, Hiroyuki Inao, Touko Yamada, Takaya Kawauchi, Hideyuki Harad...
デジタル記事
全国の図書館
- 件名Cyclophosphamide Gemcitabine T cell immunity MDSC Treg
- 一般注記Several chemotherapeutic drugs have immune-modulating effects. For example, cyclophosphamide (CP) and gemcitabine (GEM) diminish immunosuppr......ssion by regulatory T cells (Tregs) and myelo......ved suppressor cells (MDSCs), respectively. Here, we show that intermittent (metronomic) chemotherapy with low-dose CP plus GEM can induce anti-tumor T cell immunity in CT26 colon carcinoma-bearing mice. Although no significant growth suppression was observed by injections of CP (100 mg/kg) at 8-day intervals or those of CP (50 mg/kg) at 4-day intervals, CP injection (100 mg/kg) increased the frequency of tumor peptide-specific T lympho...
- 著者標目Tongu, Miki Hara......onma, Hiroyuki Inao, Touko Yamada, Takaya Kawauchi, Hideyuki Harad...
デジタル記事
全国の図書館
- 件名Cancer Research Oncology Immunolo...
- 参照Contrasting effects of cyclophosphamide on anti‐<scp>CTL</scp>‐associated protein 4 blockade therapy in two mouse tumor models Intraperitoneal Administration of a Tumor-Associated Antigen SART3, CD40L, and G......ded Polyplex Micelle Elicits a Vaccine Effect in Mouse Tumor Models Modulation of antitumor immunity contributes to the enhanced therapeutic efficacy of ......osomal oxaliplatin in mouse model Critical Roles of Chemoresistant Effector and Regulatory T Cells in Antitumor Immunity after Lymphodepleting Chemotherapy Intermittent chemotherapy can retain the therapeutic potential of anti‐<scp>CD</scp>137 antibody during the late tumor‐be...
- 参照...rcinomas. Intratumoral Injection of CpG Oligonucleotides Induces the Differentiation and Reduces the Immunosuppressive Activity of Myeloid-De......ved Suppressor Cells CD4<sup>+</su......>+</sup> regulatory T cells suppress tumor immunity but are sensitive to cyclophosphamide which allows immunotherapy of established tumors to be curative Specific destruction of host-reactive mature T cells of donor origin prevents graft-versus-host disease in cyclophosphamide-induced tolerant mice. Single administration of low dose cyclophosphamide augments the antitumor effect of dendritic cell vaccine Cyclophosphamide Augments Antitumor Immunity: ...
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