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- 要約等"This book focuses on C-type lectin receptors, a newly emerging family of pat......rn-recognition receptors (PRRs) and a c......t of the human innate immune sys......ighlight these receptors' role in the recognitio......he first steps in responding to foreign an......ous structures in the human body......rs chiefly examine various C-type lectin receptors, their corresponding ligands, and signalling. In addition to offering immunologists and clinicians important insights from the......rovide novel points of departure for future dru...
- 内容細目C-type lectin receptors in phagocytosis /......d M. Underhill C-type lectins in immunity to lung pathogens / Benjamin B.A. Raymond, ......Rombouts Signaling C-type lectin receptors in antifungal immunity / Maxine A. Höft, J. Claire Hoving, and Gordon D......l immunoactivating receptor / Ke......o Yamasaki Sensing tissue damage by myeloid C-type lectin receptors / Carlos Del F...... mechanisms of C-type lectins / Masamichi N......of CARD9 signaling in the innate immune system / Larsen Vo...
- 件名Lectins Immune recogn......ion Immunology Infection Human p......ncer--Research Infectious Diseases Receptors Human Physiolo......munology. Proteins.
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- 要約等...脂質に特異的な三つのCLR、Mincle, DCAR, Dectin-2に焦点を当て、構造生物学的観点からリガンド認識機構を概説...
- 件名C-type lectin glycan glycolipid 3D structur...
- 参照Identification of Distinct Ligands for the C-type Lectin Receptors Mincle and Dectin-2 in the Pathogenic......gus Malassezia C-Type Lectin Receptor DCAR ......l Phosphatidyl-Inositol Mannosid......h1 Response during Infection Dectin-2 Is a Direct ......Capped Lipoarabinomannan of Myco......Glycans Signalling versatility following self and non-self sensing by myeloid C-type lectin receptors Identification of lectin-like receptors expressed by antigen presenting cells and neu...... and their mapping to a novel gene complex
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- 参照...obacteria The kinetics of signaling through the common FcRγ chain determine cytokine profiles in dendritic cells
- 著者標目Carlos del Fresno Salvador Iborra Paula Saz-Leal María Martínez-López David Sancho
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- 内容細目Basic mechanisms underlying induction, progre......ion of chronic inflammation Prostaglandins in chronic inflammation Tomo......sms of chronic inflammation-asso......4A and chronic inflammation Dais......oh 著 MicroRNAs in chronic inflammation Y. I......section of autoinflammatory synd......ogy of chronic inflammation-associated signalling pathways Reiy...... Lipid signals in the resolution of inflammation Mako......ion of chronic inflammation by c......ively regulate inflammatory resp......raishi ほか著 Imaging analyses of chronic inflammation Macr......ge dynamics during bone resorption and chronic inflammation Junichi Kikuta, Kei...
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- 内容細目...eoglycan signaling networks / Arye Elfenbein and Michael Si......can dally-like in wingless/Wnt signaling and distribut......elenkaya, and Xinhua Lin Use of a phage......lycomics profiling of heparan su......cular patterns in innate immunity: extraction an......harides / Cristina De Castro . [......sis of glycosphingolipids of Sch......ssays for fruiting body lectins and other cytoplasmic proteins / Markus Künz......ohydrate signaling by C-type lectin DC-SIGN affect......y / Sonja I. Gringhuis and Teuni......Geijtenbeek Engineered carbohydr......ecognition domains for glycoprot......ds for glycan-binding receptors / Alex S. Powle...
- タイトル標目Methods in enzymology ; v. 480.
- 典拠情報（Author Heading/「を見よ」参照）Fukuda, Minoru Minoru Fukuda Fukuda, M
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- DOI10.1016/j.intimp.2013.04.013
- 参照Targeting C-Type Lectin Receptors for Cancer Immunity Effects of ionizing radiation on retinoic acid-inducible gene-I-like receptors Ionizing radiation aff......n of Toll-like receptors 2 and 4 in human monocyti......gh c-Jun N-terminal kinase activation ......ted Ca2+ Signaling in Intestinal Epithelial Cells In Vivo
- 著者標目Huimin Yan Naohito Ohno Noriko M. Ts...
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- 要約等...es to pathogen invasion or tissu......Members of the C-type lectin receptor (CLR)......he specialized receptors utilized by my......s. CLR ligands include carbohydrate, protein, and lipid com......phagocytic, proinflammatory, or anti-inflammatory reac...... for CLR signaling that includes tyrosine-based motifs that recruit kinases, phosphata......ell as nontyrosine-based signals......the uptake machinery. Here, we r......view the signaling properties of...... myeloid cells in innate and adaptive immunity.</jats:p>
- 参照Molecular determinants of sterile inflammation C-Type Lectin Receptor DCAR ......l Phosphatidyl-Inositol Mannosid......h1 Response during Infection Structu......gnition by the C-type lectins Mincle and MCL Leishmania Uses Mincle to Target an Inhibitory ITAM Signaling Pathway in Dendritic Cell......mpens Adaptive Immunity to Infection Recognition of Bisecting N-Acetylglucosamine Targeting C-Type Lectin Receptors for Cancer Immunity β-Glucan-induced cooperati......ization of Dectin-1 C-type lectin-like domain TARM1 contribu......itis by activating dendritic cel......ription by calcineurin in dendritic cells through inactivation of CREB Dendritic c...
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- 要約等...rn recognition receptors in the host immun......hese it is the C-type lectin receptors (CLRs) whose f......pes of ligands including glycans, glyc......ipids and proteins <i>via</i> small C-type lectin domains and to then t......y various CLRs involved in the immune response. In this review, I briefly introduce structu...... of three CLRs involved in mycobacterial infection. These are Mincle, DCAR and Dectin-2. Mincle binds trehalose di......, but it also binds to various (......revealed that Mincle has a sugar binding site that rec......es the acyl chains. DCAR interacts with an......dyl-<i>myo</i>-inositol mannoside. DCAR also ac...
- 件名リガンド認識 三次元構造 糖脂質 糖鎖 C型レクチン ligand recognition 3D structure glycolipid glycan C-type lectin
- 並列タイトル等（連結）Structural Aspects of Glycolipid Recognition of C-type Lectin Receptors in the Immune System
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- 要約等...rn recognition receptors in the host immun......hese it is the C-type lectin receptors (CLRs) whose f......pes of ligands including glycans, glyc......ipids and proteins <i>via</i> small C-type lectin domains and to then t......y various CLRs involved in the immune response. In this review, I briefly introduce structu...... of three CLRs involved in mycobacterial infection. These are Mincle, DCAR and Dectin-2. Mincle binds trehalose di......, but it also binds to various (......revealed that Mincle has a sugar binding site that rec......es the acyl chains. DCAR interacts with an......dyl-<i>myo</i>-inositol mannoside. DCAR also ac...
- 件名ligand recognition 3D structure glycolipid glycan C-type lectin
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- 要約等<jats:p>C‐type lectin receptors (CLRs) belong ......rn recognition receptors (PRRs). They h......l role to play in the regulation......ical functions including development, ...... angiogenesis, inflammation, and immunity. CLRs can recognize distinct and conserve......atterns. These interactions set ......wnstream signaling cascades, leading to the production of inflammatory medi......sis. CLR signaling must be tight...... the excessive inflammatory burden and to maintain the cellular h......wnstream signaling. The delicate...... seems crucial in almost all asp......dysregulations in the miRNA‐CLR ......morigenesis or inflammatory diseases. Here, we ...
- 参照Epigenetic and Transcriptional Regulation of Innate Immunity in Cancer
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- 要約等<jats:p>There is increasing interest in understanding the mechanisms underlying the interactions that......talic>and host innate immune cel......rn recognition receptors (PRRs) which r...... and which can influence the hos......esponse to the infection. Althou......o be redundant in the control of......s</jats:italic>infection<jats:italic>in vivo</jats:ita......k/CARD9 signalling pathway in antimycobacterial immunity. Here we revie......as recent data investigating the role of t......een implicated in mycobacterial recognition, including Dectin-1 and Mincle.</jats:p>
- 件名General Medicine Immunology Immunology and Al...
- 参照β-Glucans in food modify co...... microflora by inducing antimicrobial protein, calprotectin, in a Dectin-1-induced-IL-17F-de......ner Macrophage-Inducible C-Type Lectin Mincle-Expressing Dendritic Cel......rium bovis BCG Infection in Mice
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- 参照Bacterial Translocation in Gastrointestinal Cancers and Cancer Treatmen...
- 著者標目Marion Drouin Javier Saenz Elise Chiffoleau
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- 件名Infectious Diseases Microbiology...
- 参照...d by IL-17 but independent of fungal innate immune receptors Recognition of......l Immunoactivating Receptor Inherited CARD9 Deficiency in a Child with Invasive Disease ......ymptomatic Siblings Dectin-2-mediated initiation of imm......nses caused by influenza virus hemagglutinin
- 参照Identification of Distinct Ligands for the C-type Lectin Receptors Mincle and Dectin-2 in the Pathogenic......gnition by the C-type lectins Mincle and MCL Leishmania Uses Mincle to Target an Inhibitory ITAM Signaling Pathway in Dendritic Cell......mpens Adaptive Immunity to Infection Dectin-2-dependent host defense in mice infected with ser......cus pneumoniae C-Type Lectin Receptor Dectin-2 Binds to an Endogenous Protein β-Glucuronidas......itic Cells Cloning of a Second D......ell-associated C-type Lectin (Dectin-2) and Its Alt......n Receptor Dectin-1 Recognizes S......fumigatus Syk kinase is required......aborative cytokine production induced through D...
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- 参照Adjuvant effect in aquaculture fi......l Immunoactivating Receptor
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- 参照...l-Targeted Vaccine as an Alterna......l-Targeted Vaccines
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- 件名Cell Biology Clinical Biochemistry Pulmonary and Respiratory Medicine Molecular Biology
- 参照Identification of Distinct Ligands for the C-type Lectin Receptors Mincle and Dectin-2 in the Pathogenic......gus Malassezia C-Type Lectin Receptors Differentially Induce Th17 Cells and Vaccine Immunity to the Endemic......l transduction Independent risk ......neumocystis carinii pneumonia as......utrophilia Cloning of a Second D......ell-associated C-type Lectin (Dectin-2) and Its Alt......d Isoforms Dectin-2 Deficiency P......esponse and Mucin Production in the Lungs after Pulmonary Infection with Cr......: Human Fungal Infections The Interaction of <i......s</i> with the C-Type Lectin Receptor Mincle Exerts a Significant Role ...
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- 要約等...we demonstrate in vitro and in vivo that dend......ptor (DCIR), a C-type lectin receptor expre......DCs, modulates immunity to TB by sustaining type I IFN signaling in DCs. These findings were general......zed beyond TB, in a model of in vivo antigen-p...... , suggesting that they may...... such as viral infections or aut....... Thus, modulating DCIR activity......pe I IFN-targeting therapies for...... repertoire of inflammatory disorders, including TB. </jats:p>
- 件名Multidisciplinary
- 参照...l Immunoactivating Receptor Immu......ipids Through Mincle Myeloid C-type lectin receptors in skin/mucoepithelial diseases and t...
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- 件名Infectious Diseases Microbiology...
- 参照Human Dectin-1 deficiency i......ted defense against phaeohyphomy......ote antifungal immunity via IL-1β- and CXCL1-mediated...
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- 要約等...o be important in regulating Hp-mediated inflammation, but its interaction with ......ells (DCs) remains to be determined. To this end......s:italic> (Hp) infected gastric ......s) and DCs was investigated. Pri......d DCs were obtained from healthy individuals. Levels of cytokines and prostaglandin E<jats:sub>2</...... by ELISA, and C-type lectin expression in GSCs was asses......istochemistry. In a trans-well c......ltured with Hp-infected GSCs (Hp......ossess the priming effect, which could be inhibited by anti-COLEC12 (Collectin subfamily memb......>; HP0651) strain of Hp was used...... stromal cells in cancerous tissues. Hp-GSCs-co...
- 件名Multidisciplinary
- 参照...tility of Preclinical Models to Understand Carcinogenesis and to Direct Managem...