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インターネットで読める国立国会図書館全国の図書館
- 並列タイトル等（連結）新しいゲノム編集ツールであるnickase-Cas9およびnuclease dead-Cas9を用いたB型肝炎ウイルスを標的とした治療法の確立に関する研究
- 並列タイトル等新しいゲノム編集ツールであるnickase-Cas9およびnuclease dead-Cas9を用いたB型肝炎ウイルスを標的とした治療法の確立に関する研究
デジタル記事
インターネットで読める全国の図書館
- 要約等...Ono, C. et al. Suppression of HBV replication by the expression of nickase- and nuclease dead-Cas9. Sci Rep 7, 61......mplete removal of hepatitis B virus (HBV) DNA from nucl......i is difficult by the current therapies. Recent ......tem can cleave the HBV genome in vitr......ver, induction of a double-stran......break (DSB) on the targeted genome by Cas9 risks undesirable off-target cleavage on the host genome. N...... single strand of DNA, and thereby two sgRNAs are......d Cas9-induced off-target mutage......s, we examined the effects of the expressions of nickase-Cas9 and nuclease dead Cas9 (d-C......with sgRNAs on HBV replication. The expression o...
デジタル記事
全国の図書館
- 要約等...mplete removal of hepatitis B virus (HBV) DNA from nucl......i is difficult by the current therapies. Recent ......tem can cleave the HBV genome <jats:i......ver, induction of a double-stran......break (DSB) on the targeted genome by Cas9 risks undesirable off-target cleavage on the host genome. N...... single strand of DNA, and thereby two sgRNAs are......d Cas9-induced off-target mutage......s, we examined the effects of the expressions of nickase-Cas9 and nuclease dead Cas9 (d-C......with sgRNAs on HBV replication. The expression of nickase-Cas9 with a pair of sgRNAs cleaved the target HBV genome and suppressed the vir...
- 参照... transcription of hepatitis B virus by inhibiting hep......lex Guide RNAs of CRISPR/Cas9 Ef......efficient Cas9 expression mediated by excisional sys......vector and Cre The evolution of surgical treatment for gastro...
デジタル記事
インターネットで読める全国の図書館
- 一般注記...Ono, C. et al. Suppression of HBV replication by the expression of nickase- and nuclease dead-Cas9. Sci Rep 7, 61......mplete removal of hepatitis B virus (HBV) DNA from nucl......i is difficult by the current therapies. Recent ......tem can cleave the HBV genome in vitr......ver, induction of a double-stran......break (DSB) on the targeted genome by Cas9 risks undesirable off-target cleavage on the host genome. N...... single strand of DNA, and thereby two sgRNAs are......d Cas9-induced off-target mutage......s, we examined the effects of the expressions of nickase-Cas9 and nuclease dead Cas9 (d-C......with sgRNAs on HBV replication. The expression o...
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