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インターネットで読める全国の図書館
- 要約等8-Oxoguanine (8-oxoG), a major oxidative base lesion, is highly accumulated in Alzheimer’s disease (AD) brains during the pathogenic process. MTH1 hydrolyzes 8-o......to 8-oxo-dGMP, thereby avoiding 8-oxo-dG incorporation into DNA. 8-OxoG DNA glycosylase-1 (OGG1) excises 8-oxoG paired with cytosine in DNA, thereby minimizing 8-oxoG accumulation in DNA. Levels of MTH1 and OGG1 are significantly reduced in the brains of sporadic AD cases. To understand how 8-oxoG accumulation in the genome is involved in AD pathogenesis, we established an AD mouse model with knockout of Mth1 and Ogg1 genes in a 3xTg-AD background. MTH1 and OGG1 de...
- 著者標目岡, 素雅子 Leon, Julio 作見, 邦彦 Abolhassani, Nona Sheng, Zijing 土本, 大介 LaFerla, M. Frank 中別府, 雄作
- 出版者（掲載誌）Nature Research
デジタル記事
インターネットで読める全国の図書館
- 著者標目岡, 素雅子 Leon, Julio 作見, 邦彦 Abolhassani, Nona Sheng, Zijing 土本, 大介 LaFerla, M. Frank 中別府, 雄作
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