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- 一般注記...ponsible for X inactivation, is a key epigenetic player in the embryogenesis of female mammals. Of the several repeats conserved in Xist RNA, the A-repeat has b...... for its silencing function in differentiating embryonic ste......ells. Here, we introduced a new Xist allele into mouse that produces ......d Xist RNA lacking the A-repeat (Xist...... RNA expressed in the embryo coated the X chromosome b....... Although imprinted X inactivation was ......ecific RNA-seq in the trophoblast revealed that ...... RNA still retained some silencing ability. Furthermore, the failure of imprinted X inactivation had ......re significant impacts than expected on genome-wide...
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- 要約等...ponsible for X inactivation is one of the most important epigenetic players for embryogenesis of female mammals. Of the several repeats conserved in Xist RNA, the A-repeat has b...... for its silencing function in differentiating ES cells. Here, we introduced a new Xist allele into the mouse, which produce......d Xist RNA lacking the A-repeat (Xist...... RNA expressed in the embryo coated the X chromosome b....... Although imprinted X inactivation was ......ecific RNA-seq in the trophoblast revealed that ...... RNA still retained some silencing ability. Furthermore, the failure of imprinted X inactivation had more significan...
- 参照Genome-wide stability of the DNA replication program in single mammalian c......Role of SmcHD1 in establishment of epigenetic states required for the maintenance of the X-inactivated state in mice SmcHD1 underlies the formation of H......9me3 blocks on the inactive X chromosome in mice Mapping replication timing domains genome wide in single mammalian cells with single-cell DNA re......ication sequencing Ectopic Splicing Disturbs the Function of Xi......A to Establish the Stable Heterochromatin State A symmet......le switch explains the onset of random X inactivation in different mammals The 5′ region of <......st</i> RNA has the potential to associate with c...
- 参照...phenotypes and gene regulation Exploring single-sample SNP and INDEL calling with whole-ge...... developmental regulation of X-chromosome inactivation Human inactive X chromo......through a PRC2-independent SMCHD......1 pathway Impeding <......xpression from the Active X Chromosome Improves Mouse Somatic Cell N......promoter is dominated by <i>Xist......t and exhibits the parent-of-origin effects The Sequence Align......Systematic and integrative analysis of large gene lists using DAVID bioinformatics resou......mporal changes in the pattern of X-c......replication during the early post-imp......development of the female mouse The inactive X c...
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