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デジタル博士論文障害者向け資料あり
国立国会図書館
- DOIinfo:doi/10.1038/s41598-017-1799...
- 国立国会図書館永続的識別子info:ndljp/pid/11178474
- 一般注記Alzheimer's disease (AD) is the most common form of dementia, characterized by accumulation of amyloid β (Aβ) and neurofibrillary tangles. Oxidative stress and inflammation are considered to play an important role in the development and progression of AD. However, the......tribute to the Aβ pathologies remains unclear. We performed inter-species comparative gene expression profiling between AD patient brains and the App^<NL-G-F/NL-G-F> and 3xTg-AD-H mouse models. Genes commonly altered in App^<NL-G-F/NL-G-F> and human AD cortices correlated with the inflammatory response or immunological disease. Among them, expression of AD...
デジタル記事
インターネットで読める全国の図書館
- 要約等<jats:title>Abstract</jats:title><jats:p>Alzheimer’s disease (AD) is the most common form of dementia, characterized by accumulation of amyloid β (Aβ) and neurofibrillary tangles. Oxidative stress and inflammation are considered to play an important role in the development and progression of AD. However, the......tribute to the Aβ pathologies remains unclear. We performed inter-species comparative gene expression profiling between AD patient brains and the<jats:italic>App</jats:italic><jats:sup>NL-G-F/NL-G-F</jats:sup>and 3xTg-AD-H mouse models. Genes commonly altered in<jats:italic>App</jats:italic><jats:sup>NL-G-F/NL-G-F</j...
- 件名Multidisciplinary
- 参照Microglial gene signature reveals loss of homeostatic microglia associated with neurodegeneration of Alzheimer’s disease The KEAP1-NRF2 System in Healthy Aging and Longevity Multifactorial glial responses and their contributions to Alzheimer's disease continuum Nrf2 Suppresses Oxidative Stress and Inflammation in <i>App</i> Knock-In Alzheimer’s Disease Model Mice The KEAP1-NRF2 system and neurodegenerative diseases Transferrin Biosynthesized in the Brain Is a Novel Biomarker for Alzheimer’s Disease Molecular Pathophysiology of Insulin Depletion, Mitochondrial Dysfunction, and Oxidative Stress in Alzheimer’s Disease Brain Mic...
デジタル博士論文
インターネットで読める全国の図書館
- 目次・記事med3153.pdf med3153_abstract.pdf med3153_review.pdf
- 並列タイトル等（連結）Comparative profiling of cortical gene expression in Alzheimer's disease patients and mouse models demonstrates a link between amyloidosis and neuroinflammation
- 並列タイトル等Comparative profiling of cortical gene expression in Alzheimer's disease patients and mouse models demonstrates a link between amyloidosis and neuroinflammation
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