検索結果 3 件
デジタル記事
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- 要約等8-Oxoguanine, a major oxidized base lesion formed by reactive......sion mutations or leads to cell death in mammals if it accumulates in DNA. 8-Oxoguanine can originate as 8-oxo-dGTP, formed in the nucleotide pool, or by direct oxidation of the DNA guanine base. MTH1, a......o-dGTP hydrolyzing activity, 8-oxoguanine DNA glycosylase (OGG1) an 8-oxoG DNA glycosylase, and MutY homolog (......UTYH) with adenine DNA glycosylase activity, minimize the accumulation of 8-oxoG in DNA; deficiencies in these enzymes increase spontaneous and induced tumorigenesis suscep......e different tumorigenesis susceptibilities. These can be reversed by combined...
- 件名oxidative stress nucleotide pool nuclear DNA mitochondrial DNA MTH1 OGG1 MUTYH mutagenesis 8-oxoguanine programed cell death
デジタル記事
インターネットで読める全国の図書館
- 件名oxidative stress nucleotide pool nuclear DNA mitochondrial DNA MTH1 OGG1 MUTYH mutagenesis 8-oxoguanine programed cell death
- 関連情報http://doi.org/10.3390/ijms150712543
デジタル記事
インターネットで読める全国の図書館
- 件名Inorganic Chemistry Organic Chemistry Physical and Theoretical Chemistr......y General Medicine Catalysis
- 参照8-oxoguanine DNA glycosylase (O......ency elicits coordinated changes in lipid and mitochondrial metabolism in muscle Epigene...... modifications in DNA could mimic oxidative DNA damage: A double-edged sword MTH1 as a nucleotide pool sanitizing enzyme: Friend or foe? Structural and Kinetic Studies of the Human Nudix Hy......se MTH1 Reveal the Mechanism for Its Broad Subs......ty Proteomic profiling of small-molecule inhibitors reveals dispensability of MTH1 for cancer cell survival Molecular pathophysiology of impaired gluco......l dysfunction, and oxidative DNA damage in Alzheimer's disease brain Discovery of a new class of M...
- 参照... broadband UVB independent of Ogg1 genotype 8-Oxoguanine causes neurodegeneration during MUTYH-mediated DNA base excision ......pair MutT protein specifically h......nic substrate for DNA synthesis Hydrolytic elimination of a mutagenic nucleotide, 8-oxodGTP, by......ilodalton protein: sanitization of nucleotide pool. Expression of human MutT hom......e (hMTH1) protein in primary non-sm......-cell lung carcinomas and histologically normal surrounding tissue Human ......utY Homolog, a DNA Glycosylase Involved in Base Excision ......ir, Physically and Functionally Interacts with Mi......ch Repair Proteins Human MutS Homolog 2/Human M...
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