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紙図書
国立国会図書館全国の図書館
- 要約等... immune checkpoints and offers n...... immune checkpoints: T lymphocyt......ted antigen-4 (CTLA-4) and programme...... antibodies against these two mo......ghly effective in the treatment ...... that PD-1 and CTLA-4 have been linked to the supp......receptor signaling and co-stimul......the volume examines other agents......tors and signaling molecules, that are also involved in the regulation...... immune checkpoints to 'molecule......tivation'. Playing essential roles in immune homeost......the therapy of autoimmune diseases. Written by internationally r...... scientists, clinicians, drug development resea...
- 内容細目...f LAG-3-expressing, IL-10-producing regulatory T ......s Role of PD-1 in immunity and diseases CTLA-4, an essential immune-checkpoint for T cell ac......tor of T cells in autoimmunity and cancer Mining the complex family of protein tyrosine phosphatases for checkpoint regulators in immunity Immun......tion by ubiquitin tagging as checkpoint code MicroRNA in immune regulation.
- ジャンル・形式用語Index not Present.
紙博士論文
国立国会図書館
- 並列タイトル等（連結）自己免疫性慢性甲状腺炎を合併した、日本人若年発症1型糖尿病患者におけるCTLA-4遺伝子A/G多型性の検討
- 並列タイトル等自己免疫性慢性甲状腺炎を合併した、日本人若年発症1型糖尿病患者におけるCTLA-4遺伝子A/G多型性の検討
デジタル記事
インターネットで読める全国の図書館
- 要約等...yte antigen-4 (CTLA-4), up-regulated......early fatality in germ-line CTLA-4–deficient mice, the role in adulthood remains unclear. We abrogated CTLA-4 expression in adult mice and......h congenitally CTLA-4–deleted mice. ......e two modes of CTLA-4 deficiency differed in resulting autoimmune disease phenotype and ......ally, although CTLA-4–deficient mice......evere collagen-induced arthritis......e protected against peptide-induced experimental autoimmune encephalomyeli...... onset of protein-induced EAE was o......taken together indicate that CTLA-4 deficiency affects both centr...
- 件名Multidisciplinary
- 参照...y and Function in Autoimmunity a......latory T cells in the regulation of autoimmune arthritis CTLA-4, an Essential Immune-Checkpoint for T-Cell Ac......ells and Human Disease Stimulatory and Inhibitory Co-signals in Autoimmunity I......adverse events in various organs...... immune checkpoint inhibitors
デジタル記事
全国の図書館
- 件名Genetics (clinical) Genetics Immunology
- 参照Endocrinopathies in Inborn Errors of Immunity
- 著者標目...ll A Short B Skinningsrud W Ollier K Badenhoop G M...
デジタル記事
全国の図書館
- 件名Genetics (clinical) Genetics Immunology
- 参照...ry gene CTLA4 single nucleotide ......at position 49 in exon 1 and HLA-DRB1*08 in Japanese patie......A polymorphism in the development of celiac disease in Jordanian pati......milial Graves' Disease Associated wit......lymorphism and Autoimmune Thyroid Disease in Japanese Patients
- 出版者（掲載誌）Springer Science and Business Media LLC
デジタル記事
全国の図書館
- 参照A Patient with CTLA-4 Haploinsufficiency Presenting Gastric Cance......cyte antigen 4–insufficient subjects Increased Risk for Malignancies in 131 Affected C......ic options for CTLA-4 insufficiency Imm......ovo CTLA4 germline mutation responsive to abata...
- 著者標目Sebastian Zeissig Britt-Sabina Petersen Michal Tomczak Espe...
デジタル記事
全国の図書館
- 参照Gene and protein expression of a soluble form of CTLA-4 in a healthy dog
- 著者標目Daniele Saverino Rita Simone Marcello Bagnasc...
- 出版者（掲載誌）Springer Science and Business Media LLC
デジタル記事
全国の図書館
- 要約等...:bold> Chronic autoimmune disease in humans is the ......e immune cells in the periphery.......ly achieved by inhibition of new......yte antigen‐4 (CTLA‐4) has emerged a......hat serve to maintain peripheral tolerance. CTLA‐4 expression is induced on the su......antigen‐presenting cells (APCs) ......‐cell surface. CTLA‐4 attenuates thi......ation by competing for CD28 liga......ggest that the CTLA‐4 gene is a locu......ceptibility to autoimmune disease. However, spec......tional defects in the CTLA‐4 gene in patients have ...... date. Elucidating the role of CTLA‐4 in immune toleran......, particularly in the treatment of malignancy a...
- 参照Activation-induced accumulat......ogical synapse in CD4+ T cells CTLA-4, an Essential Immune-Checkpoint for T-Cell Ac......cyte Antigen 4 in Primary Biliary Cholangitis: ...
- 著者標目Kenneth J. Scalapino David I. Daikh
記事
全国の図書館
デジタル記事
全国の図書館
- 件名Endocrinology Endocrinology, Diabetes and Metabolism
- 参照...ifferent roles in Graves’ disease and Hashimoto’s thyroiditis: ...
- 著者標目Jing Yang Qiu Qin Ni Yan Yuan-fe......ndey Peng Hou Jin-an Zhang
デジタル記事
全国の図書館
- 参照Tyrosine 201 of the cytoplasmic tail ...
- 著者標目Dan Holmberg Corrado M. Cilio Marie Lundholm Vinicius Motta
- 出版者（掲載誌）Informa UK Limited
デジタル記事
全国の図書館
- 参照...SCT TGFβ1 and sCTLA-4 levels are increased in eltrombopag-exposed patients ...
- 著者標目Daniele Saverino Renata Brizzo......i Francesca Milintenda-Floriani Giampaola Pesce...
記事
全国の図書館
- 著者標目SAVERINO D.
デジタル記事
全国の図書館
- 要約等<jats:p>CTLA-4-deficient mice......velop a lethal autoimmune lymphoprolifer......on<jats:italic>in vivo</jats:ita......s required for induction of autoimmunity. Using CTLA-4-deficient mice expressing CD28 molecule......with various point mutations in the CD28 cytos......at<jats:italic>in vivo</jats:ita......timulation for induction of autoimmune disease strictly requires an intact C-terminal proline motif that pr......-specific protein tyrosine kinase Lck binding to the CD28 c......ail, because point mutations in C-terminal proline residues (Pro......tely prevented disease induction. In contrast,<jats:italic>in vivo</jats:italic>costimulati...
- 件名Multidisciplinary
- 参照CD28 signaling in primary CD4+ T......n of both tyrosine phosphorylati......hosphorylation-independent pathw......onance of CD28 interaction with cytoplasmic ada...