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- 要約等...ntiporters are integral membrane proteins that exchange......rtually all living cells. They a......rs have become increasingly characteriz......d are now becoming important dru......erfamily, contains proteins with a surprisingly broad colle......ations, exchanging protons for a......wn to function in vivo as a spec......rter while retaining the ability t....../jats:sup>and bind (but not exch......up>+</jats:sup>in a competitive ......ese and other findings reviewed in this communica......stems to study intimate molecula......tion exchange. In an evolutionar...... entity undergoing active divergent evolution. In this minireview, to rationali...
- 件名Cell Biology Molecular Biology Biochemistry
- 参照Mrp Antiporters Have Important Roles in Diverse Bacteria and Archaea
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- 要約等<jats:p> Intrinsically disordered proteins (IDPs) are widespread in eukaryotes and......ted with signaling and regulatio......ent evidence points to a special......assist the folding of other proteins and prevent t......as chaperones. In this paper, we......survey current information avail......nction of IDPs in general, (ii) ......red chaperones in plants, (iii) ......red chaperones in other organisms spanning from insects to mammal......assist the folding of both RNA and protein substrates. Th......ost conclusive in the case of pl......nt stress proteins, such as late......ant (LEA) proteins or dehydrins. We will show that the cellu...
- 件名Cell Biology Molecular Biology Biochemistry
- 参照...ctive Activity in Human Genome-Derived Intrinsically Disordered Proteins Heme‐dependen......gnition of 5‐aminolevulinate synthase by the human mito...
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- 要約等...icutes are missing GroEL. We use......sence of GroEL in Mycoplasma may......e required for invasion of host tissue, suggesting that GroEL ma......act as an adhesin–invasin.</jats:p>
- 件名Cell Biology Molecular Biology Biochemistry
- 参照...al marker for finer differentiat......s'-related strains Difference in the distributi......strate enzymes in the metabolic ......ia coli, according to chaperonin requirement
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- 要約等<jats:p>Cysteine string protein (CSPα, also ca......e among J proteins. Similar to other J proteins, CSPα interacts with an......eat shock proteins of 70 kDa), thereby harnessing the ATPase ac......on client proteins. In contrast to other J proteins, CSPα is anch......ell as to exocrine, endocrine and neuroendocrine secretory gra......ressive misfolding of one or more client proteins. Here we high......ecent advances in our understanding of the critic......hat CSPα plays in governing exocytotic secretory functio...
- 件名Cell Biology Molecular Biology Biochemistry
- 出版者（掲載誌）Canadian Science Publishing
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- 要約等...countered when invading the host’s digestive or urinary tracts. The......based. The 3 main enzyme-based a......glutamate-, arginine-, and lysine-decarboxylase......y network allowing the bacteria to fine tune its resp......HdeB are the main chaperones involved in acid stress re......are also found in Vibrio cholera......ferences exist in their functional mechanism an...
- 件名Cell Biology Molecular Biology Biochemistry
- 参照...tnaA mRNA encoding tryptophanase......uisite for the induction of acid resistance in Escherichia coli Production o...
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- 要約等<jats:p> Protein disorder is abundant in proteomes throughout all kingdoms of life a......states of proteins are challenging to study expe......l ensembles of intrinsically disordered proteins. In this review, w......tudies of protein disorder with ......mphasis on the interdisciplinary nature of t......s is described in the context of......imental and bioinformatics appro......al data can be incorporated into simulations,......or experiment. In this way, simu......ions have been integrated into the existing methodologies......ical understanding made possible......This review is intended as both ......physicists seeking accurate, atomic-level descr...
- 件名Cell Biology Molecular Biology Biochemistry
- 参照...ansition of an Intrinsically Disorde...... Enhanced Sampling
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- 要約等<jats:p>Elastin is a self-assembling, extracellular-matrix protein that is the ma......tudies of elastin from over four......sorder that is inherent in all levels of ......eature of elastin structure and function.</jats...
- 件名Cell Biology Molecular Biology Biochemistry
- 参照...and Variations in Vascular Type and Size Seeing Elastin: A Near-Infrared Zwitteri......cent Probe for In Vivo Elastin Imaging Significance ......on of the Elastin-like Peptide A......he self‐assembling abilities of short elastin‐like peptide F......gs by substituting <i>N</i>‐terminal amino acids Elastin-derived peptides are involved in the processes ......ar disorder by inducing inflammatory responses in synovial cells......-Diameter Elastin-Silk Fibroin Vascular Grafts
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- 要約等...bution. Mitofusin-2 (Mfn2) is a ......chondrial protein involved in such fusion. R......t observations indicate that Mfn......unctional protein that participates in cell prolifera......um morphology. In relation to th......2, alterations in activity have ......nit expression in cultured nonmu......fn2 expression in skeletal muscl......pressed Mfn2 . In contrast, cold......ts or exercise induce the expres......n of this gene in muscle. Estrog......fn2 expression in muscle cells, ......downregulation in skeletal muscle and in the heart. We ......ession of Mfn2 in muscle, wherea......α participates in the stimulation of Mfn2 expre...
- 件名...y General Medicine Endocrinology, Diabetes and Metabolism
- 参照...tion of mitofusin-2 and optic atrophy-1 in multiple organs
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- 要約等... high, fluctuating, and adaptabl......s for synthesizing, transferring, and utilizing energy in accordance wit......o endurance training mainly involves energetic remodelling in skeletal muscl......e. Alterations in energy metabol......sm participate in many pathophys......e endurance training improves symp......ization, it is increasingly recognized ......The mechanisms involved in the beneficial......of exercise training are far from being understood. P......populations living in industrialized co...... This review mainly focuses on o......metabolism and intracellular energy transfer in muscles and th......ir alterations in heart failure, and the effect...
- 件名...y General Medicine Endocrinology, Diabetes and Metabolism
- 参照Fibronectin type III domain containing 5 expression in skeletal muscle in chronic heart ......e—relevance of inflammatory cytokines
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- 要約等...ontractile machine is fueled by ......ontractile machinery by binding to troponin C and relieving troponin-tropomyosin inhibition of actinomyosin interaction. ATP binding to myosin during the contracti...... cycle results in myosin detachment from actin, and energy li......cium levels during muscle relaxa......ntractility is intimately linked to the prop......) utilization. In skeletal muscl......drial function in muscle are not independent, as calcium uptake into the mitochondria increases ATP pro......ion by stimulating oxidative pho......ies (ROS/RNS), in turn, modulate......esultant anchoring of mitochondria to the CRU p...
- 件名...y General Medicine Endocrinology, Diabetes and Metabolism
- 参照Interaction between myoglobin and mitochondria in rat skeletal muscle Associati...
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- 要約等<jats:p> Understanding the mechanism......e mass has remained a focus of n...... years. Recent investigations ha......cellular signaling mechanisms th......icant effort being focused on th......rget of rapamycin (mTOR) signaling pathway. The ......s a major role in regulating the initiation of protein synthesis afte......mechanical loading of skeletal m......Akt/mTOR signaling pathway. Thus......Akt/mTOR signaling mechanism in mechanically loaded skeletal ...
- 件名...y General Medicine Endocrinology, Diabetes and Metabolism
- 参照...y Without Altering the Protein Anabolic Signaling Pathway
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- 要約等<jats:p> Acute exercise initiates rapid c......r signals, leading to the subseq......vation of proteins that increase gene tra......en observed during the recovery period following exercise. The......are translated into precursor proteins for import into preexisting mitochondria. Once inside the organelle, the protein is processed t......, serves as a single subunit enzyme, or is incorporated into multi-subuni......respiratory chain devoted to ele...... this exercise-induced sequence ......al network within muscle cells a....... An understanding of the molecular processes involved in this complex p......search undertaking in laboratories involved in ...
- 件名...y General Medicine Endocrinology, Diabetes and Metabolism
- 参照PPARβ Is Essential for Maintaining Normal Levels......ia and for the Increase in Muscle Mitochondria Induced by Exerci......fat diets containing coconut oil a......abolic effects in untrained and treadmill-trained mice Mitocho......Cyst Formation in Autosomal Dominant Polycystic ......ey Disease Distinct Gene Express......on Profile Distinguishes Increased Metabolic Activity in Spontaneously ......tary from That Induced by Exercise
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- 要約等...ese enzymes during the transcrip...... about the machinery that regula......transcription. In particular, th...... subunits, remains mostly unchar......d and the proteins involved are yet ...... discovered. Using protein affinity purificatio......a high-density interaction netwo...... the dataset using a machine learning approach trained to minimize the rate ......ncovered novel interactors that ......nscription machinery, including a set of proteins we named the ......ssociated proteins (RPAPs). One ......P3/R2TP/prefoldin-like complex. ......mplex, which points to a role in nuclear RNAP biogenesis.</jat...
- 件名Cell Biology Molecular Biology Biochemistry
- 参照RPAP3 splicing variant isoform 1 interacts with PI...... R2TP complex, inhibits doxorubicin-induced apoptosis
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- 要約等<jats:p> From a cell-signaling perspective, short-duration intense muscular ...... resistance training and linked to pathways......ssions of high-intensity interval exercise training (HIT) induce rapid phen......l endurance training. Given the ox......ld be mediated in part through signaling pathways norm......h endurance training. A key contro......yme expression in skeletal muscl......serves to coordinate mitochondri......-1α regulation in humans have us......onged exercise interventions; ho...... that a surprisingly small dose of very intense interval exercise......ent to only 2 min of all-out cycling, was sufficient to increase ...
- 件名...y General Medicine Endocrinology, Diabetes and Metabolism
- 参照... concurrent training combined with resistance and high‐intensity interval exercise on mTOR signaling and glycolytic metabolism in mouse skeletal......ercise is medicine: a new perspe......alth promotion in bipolar disord......-19 and Quarantine: Expanding Understanding of How to Stay Physically Ac...
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- 要約等...nsible for the insulin-stimulated dis......wever, identifying the link between exces......t and impaired insulin sensitivity in skeletal muscl......e-derived cytokines (adipokines) have been implicated in the impairment of insulin sensitivity, while adipokines such as leptin and adiponectin exert an insulin-sensitizing effect. Leptin and adiponectin have each been shown to increase fatty ac......ceride storage in muscle, which may explain, in part, the insulin-sensitizing effect of these cytokines. Recent evid...... implicates an increased localiz......portant factor in the accumulation of intramuscular lipids with high-f...
- 件名...y General Medicine Endocrinology, Diabetes and Metabolism
- 参照...mportant determinant affecting hepatic conditions of non-al...
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- 要約等<jats:p>The junctional domain of sarcoplasmi......ized for receiving signals from ...... and for releasing Ca<jats:sup>2+</jats:sup>during muscle activa......of the jSR, facing the transvers......hannels (ryanodine receptors); the luminal protein calsequestrin (CSQ); the 2 membrane proteins, junctin (Jct), and triadin (Tr), which me......iate CSQ-ryanodine receptor interactions; and......ditions prevailing within the sarcoplasm......SQ forms long linear polymers an......the fixed protein gel is clearly visible in the electron m......oscope. The luminal domains of Jct and Tr......not clearly delineated. Cardiac muscles either ...
- 件名...y General Medicine Endocrinology, Diabetes and Metabolism
- 参照Ca2+ microdomains organized by junctophilins
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- 要約等...l coactivator, increases the exp...... of many genes in skeletal muscle, including those involved with fat......tion. Exercise increases the exp......d the exercise-induced upregulat...... attributable, in part, to the preceding activation an......ion of PGC-1α. Indeed, PGC-1α ov......ke exercise training, increases exercis......-1α reductions in humans have been observed in type 2 diabetes, while, in cell lines, PGC-1α mimi......s the exercise-induced improvement in insulin sensitivity. H...... unexpectedly, in mammalian musc......opment of diet-induced insulin resistance. Th...... PGC-1α, which induced the upregulation of the ...
- 件名...y General Medicine Endocrinology, Diabetes and Metabolism
- 参照...enoid fucoxanthin Fucoxanthin promotes translocation and induction of gluc...... transporter 4 in skeletal muscl...... mice Fucoxanthin in the management......ssion Analysis in the Skeletal M......cles of Dysferlin-deficient SJL/J and A/J Mice
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- 要約等<jats:p>During moderate-intensity exercis...... are the predominant substrate for working skeletal musc......ue stores, combined with the abi......e to actively fine tune the grad......abolism, depending on substrate ......equires a coordinated system of ...... past decade, since the discover......activated protein kinase (AMPK) was increased in accordance with exercise intensity, there ......en significant interest in the proposed r......ent stress-sensing kinase as a critical integrative switch controlling metabolic responses during exercise. In this review, studies examining the role of A......cid metabolism in both adipose tissue and skele...
- 件名...y General Medicine Endocrinology, Diabetes and Metabolism
- 参照...w- versus high-intensity exercise training on endoplasmi......ress and GLP-1 in adolescents with type 2 diabe...
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- 目次・記事Mitochondria Protein synthesis Coding Radiation biology of microor...
- 内容細目...shimura, S. Coding v. 4. Suzuki,......aziro, Y. Protein synthesis v. 8. Tokushige, M....
- 件名Biochemistry.
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- 要約等...sembly. Predicting these forces in a given biolog......ext is challenging, since water organi...... the nanoscale in vivo. In this work, we ...... different confining surfaces, and......henomena known in the simulation literature, including several cases of protein folding under confinement. </jats:p>
- 件名Cell Biology Molecular Biology Biochemistry
- 参照Recent advances in quantum‐mechan......sfer mechanism in various water‐based environme...