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- 要約等...are implicated in the formation ......brane microdomains, where they interact with protein receptors to m......membrane signaling. Studies of g......and their protein binding affinities tend to b......ic glycolipid-binding proteins have been emp......obes for detecting lipid rafts, ......itable for probing glycolipids a......on of the retroinverso approach ...... method to obtain novel glycolipid-binding D-peptide seq......two known GM1-binding peptides by replacing L-amino acids with D-amino acids, followed by inverting the sequences......nd glycolipid binding properties. C......copic analysis indicated that all the peptide s...
- 件名retroinverso peptide glycolipid peptide-glycolipid interaction GM1 lipid raft
- 参照Detection of protein mediated glycosphingolipid clustering by the use of......lished by applying the system ga......and cholera toxin B subunit Anal...... of Cholera Toxin−Ganglioside Interactions by F...... Use of a Retroinverso p53 Peptide as an Inhibitor of MDM2......t developments in retro peptides and proteins — an ongoing topochemical ......Modified Retro-Inverso Peptides:......avior Shiga toxin induces tubular membrane invaginations for its uptake into cells Stabil......cal structures in short peptides via end capping. Crystallogra......nglioside GM1‐binding peptides by using a phage libra......amyloid β–protein (Aβ): A possible form of prea...
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- 要約等<p>The majority of kinase inhibitors have b......competitors to interact with a hinge region in ATP binding sites of kinases. 7-Azaindole has been f...... an excellent hinge binding motif by making two hydrogen ......onds with the kinase hinge region. Vemu......enib, a B-RAF kinase (serine–threonine kinase [STK]) inhibitor approve......od and Drug Administration (FDA)......is simple 7-azaindole fragment b......ential of 7-azaindole as a hinge-binding motif has enc......mploy it as a kinase privileged ......amples of 7-azaindole-based kinase inhibitors, and d......scusses their binding interactions with the kinase hinge regions.</p>
- 件名kinase inhibitor azaindole hinge binder fragment-based drug discov...
- 参照Photosensitized Intramolecular [2......-<i>b</i>]pyridines Enabled by t......-Methoxybenzyl)indoles and azaindoles with nitrile oxides
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- 要約等...idely utilized in various scient......ecent advances in the direct deu...... derivatives using heterogeneous platinum group metal ......nge reactions. In this review, t......of catalysts using <i>in situ</i>-gener......of alcohols is introduced. The obtained multiple deu......eled products, including bioactive com......any scientific investigations.</p>
- 件名deuterium labeling heterogeneous catalyst deute...
- 参照Robust Continuous-Flow Synth......on Exchange Resin Platinum on carbon-ca......lic alcohols using alkyl amines as a hydroge......erium‐labeled cinnamic acids: Understanding the volatile ......zenoid pathway in the flowers of......></scp> Recent Progress in the Synthesis ...... Efficient Continuous-Flow H–D E......romatic Nuclei in D2O/2-PrOH Mixed Solvent in a Catalyst Car......acked with Platinum on Carbon Be......sotope Effects in Keto-Enol Taut......Nuclei— Hydroquinone and benzoquinone-catalyzed a......l condensation Investigation of ......ihydrogenation in a Proton-Excha...... Reactor Utilizing Bayesian Optimization Birch-...
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- 要約等<p>Among the muscarinic acetylcholine receptor (mAC......eptor has been investigated as a promising drug target f......phrenia. These investigations ha......been based on findings from M<sub>4......results of a clinical trial that used xanomeline, an M<sub>1</...... mAChRs-preferring agonist. Both......orted as promising ligands that ......challenges remain due to the hig......e orthosteric binding site among all muscarinic receptors. In this review, w......ChR structural information and s......tudies. These findings indicate that sel......tors are promising potential therapeutic agents...
- 件名M₄ muscarinic acetylcholine receptor selective activator...
- 参照M4 muscarinic receptor kno......eased prepulse inhibition Discov......-sulfonyl-7-azaindoline derivatives a......ctive M4 muscarinic acetylcholine receptor agon......human M2 muscarinic acetylcholine receptor boun......ry of dihydroquinazolinone derivatives......1 and M4 muscarinic acetylcholine receptors ago......ent of D1 dopamine receptor-medi......or stimulation in M ...... muscarinic acetylcholine receptor knockout mice Involvement of a ......b>4</sub>Muscarinic Acetylcholine Receptors in the Antipsycho......>4</sub>Preferring Muscarinic Receptor Agonist Xanomeline Molecular Biology of Muscarinic Acetylcholine Receptors Xan...
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- 内容細目Front Cover; Fluorine in Life Sciences:......armaceuticals, Medicinal Diagnostics, a......hemicals; Fluorine in Life Sciences:......harmaceuticals,Medicinal Diagnostics,an......reface; 1 Emerging fluorination methods in organic chemistry relevant for l......pplication; 1. Introduction; 2. ......leophilic fluorination sources; ......trophilic fluorination sources; 3. Fluorination of prefun......catalyzed fluorination of aryl h......atic deoxyfluorination: PhenoFlu......oxylative fluorination of hetero......cles; 3.6 Fluorination of aryl b......ives; 3.7 Fluorination of aryl s......anes; 3.8 Fluorination of aryl silanes; 3.9 Flu...
- 件名Fluorine. Fluorine--Physiological effect. SCIENCE / Chemistry / Inorganic.
- 一般注記3.3.1 Fenfluramine (1973, 70) and Tiflorex (Flutiorex, 71). Includes index.
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- 内容細目...eases: repurposing knowledge, me......herapeutics to increase discover......y / David C. Swinney, Michael P....... of zika virus infection: lesson......e Deval Developing therapeutics ......rickson, Christina F Spiropoulou Part II. Kinetoplastids. Designing drugs to targ...... disease: when chemistry needs biology / Martine Keenan, Eric Chatelain Drug discovery....../ Andrew Spaulding, Mitchell F. Gallerstein, Lori Ferrins Discovery of ......ishmaniases: a progress report / Baljinder Singh, Frederick S...... Part III. Helminths. Onchocerci......ja Becker, Martin Schlitzer, Dav......toph G. Grevelding Soil-transmitted helminthias...
- 件名Tropical medicine. Drug development. Tropical Medicine. Drug Development.
- タイトル標目Methods and principles in medicinal chemistry ; v. 77.
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- 要約等...harmaceuticals in cancer, dental...... The book also includes the tran......oes on to explain the toxicity o......rgan systems using examples of in vivo systems
- 内容細目Chapter 1 Inorganic Nanomat......osis Chapter 3 Insights into nanotools for dental interventions Cha......rs as Carriers in Dermal Drug De......ew of research innovations and b......its Assessment in Animal Models ......ort across the intestinal barrier Chapter 10 Recent Progress in Nano-theranostic medicine
- 件名...nment. Polymer chemistry. Water supply ......echnology & Engineering--Textiles & P......echnology & Engineering--Environmental--General.
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- 件名Pharmaceutical chemistry
- 件名（識別子）Pharmaceutical chemistry
- 一般注記Includes index
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- 内容細目Natural products in drug discovery......ern approaches in the search for......lead compounds in medicinal chemistry / Eliezer J. B......ural compounds in drug discovery......tural products in discovery of new anti-infective agents ......aximiliano Sortino ... [et al.] ......s / Luiz C. Klein-Junior, José R. Santin and Sérgio F.......Andrade Recent progress in the chemistry and biology of......nd David G.I. Kingston Cancer ch...... / A. Douglas Kinghorn ... [et al.] Medicinal plants and pha......y / Ruth M. Lucinda da Silva, An......nia M.B. Bresolin Natural products in clinical trials / S...... Chrubasik The influence of biotic and abiotic ...
- 件名...Pharmaceutical chemistry. Plants, Medicinal--metabolism. Drug Discovery. ...
- タイトル標目Wiley series in drug discovery and developmen...
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- 内容細目Recent advances in carbocyclic nu......activity / Jianing Wang, Ravindra K. Rawal, a......n Huang Unraveling of the NAD cyclizing and calcium signaling functions of ......e DNA and RNA binding small molecul......nd its ligands in anticancer the......Molecular modeling in nucleic acid t...... 10-23 DNAzyme in complex with the target RNA in silico : a progress report on the ......opadhyaya Labeling oligonucleoti......ides towards clinical applicatio......l The pharmacokinetics researche....../ Shengqi Wang Inducible RNAi and drug target v...
- 件名Pharmaceutical chemistry. Nucleic acids -- Therapeutic...
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- 内容細目Designing a diverse hig......sed FBDD screening Preparation of protein samples for NM......molecule screening studies Key f......ration of protein-fragment struc......rement on protein, crystals, and......hnology Predicting the success o......fragment screening by X-ray crys......Fragment screening of stabilized G-protein-coupled receptors using biophysical methods Using computational techniques in fragment-based......void rediscovering the known Fro......entification using surface plasm......fragment screening Binding site identifi......tructure determination of protein-ligand complex...... approach Protein thermal shifts to identify lo...
- タイトル標目Methods in enzymology ; v. 493.
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- 内容細目Disseminated tumor cell......ecent advances in nuclear medicine: radiopharmaceutical chemistry of agents used for lymphoscintigraphy and the sentinel node biopsy ......00 family proteins in tumour progression / Noona Amb...... Eugene Lukanidin Association of......s and survival in renal cell carcinoma / Minna Kankuri-Tamm......f nucleic acid in colorectal can......rrant MUC1 bearing Tn antigen in rat ascites he......lar risk profiling in gastrointestinal cancer / Rol......pidemiology, clinical presentation and imaging / J.P. Van Me......eeck, R. Gosselin and Ph.Duyck B......astases / Cristina Nadal, Jurrian van Dam and J...
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- 要約等The increasing incidence of vancomycin resistance in clinical settings has prompted research into new antibiotics against vancomycin–resistant strains. Recent effor......de antibiotics including our works are reviewed. Introduction of a......tuent at the amino acid residue 2 of vancomycin by Suzuki–Miyaura cross–coupling reaction led ......al activity against vancomycin–resistant <I>S......of Van–M–02 against the Gram–positive bacteria including vancomycin–resistant ente...... of action was investigated with......y system employing cell–membrane fraction of <I...
- 件名VRE VRSA vancomycin antibiotics Suzuki-Miyaura cross-coupling Van-M-02 S. aureus mode of a...
- 参照...ipid II: The Final Monomeric Intermediate in Bacterial Cell......p>d</scp>-Lac Binding Is Not Requir......ity of Vancomycin Dimers against Vancomycin Resistant Ente......nogashira Coupling Reactions of ......d for the Coupling of Challenging Substrate Combinations in Water Polyvalent Interactions in Biological Sys......nt Ligands and Inhibitors Discov......thetic Vancomycin Derivatives Effective against Vancomycin-Resistant Bact......l Glycopeptide Inhibitor of Pept......can Synthesis, in Vancomycin-Resistant Bacteria Telavancin: An Antimicrob...... Gram‐Positive Infections Multiv...... Synthesis and In Vitro Analysis of an Array of...
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- 件名Pharmacology Molecular Medicine Drug Discovery Biochemistry Organic Chemistry
- 参照Design, Synthesis, Radiolabeling, and in Vivo Evaluatio......4-(3-Cyanopyridin-2-yl)piperazin-1-yl]ethyl]-3-......r for the Dopamine D<sub>4</sub> Receptors
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- 件名Organic Chemistry Clinical Biochemistry Drug Discovery......Molecular Medicine Biochemistry
- 参照Synthesis of isoxazoloazaborines <i>via</i> g......ura cross-coupling of 3,4-disubstituted 5-bromo...
- 著者標目Jie Zhu Jun Mo Hong-zhi Lin Yao Chen Hao-peng Sun
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- 件名Drug Discovery General Medicine
- 参照...lycerylated lysine residues using structural properties of amino acids EvolStruct-Phogly: incorporating structural pr......d evolutionary information from ......e prediction using half-sphere exposures of amino acids residue......ediction of Lysine Phosphoglycer......ix PREvaIL, an integrative approach for inferring catalytic residues using sequence, str......twork features in a machine-learning framework Sum......lation Sites Using Predicted Secondary Structur...
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- 要約等...the most promising strategies am......ious ‘elements chemistry’ approaches fo...... novel and distinctive drug cand......tion) has been intensively studi......bolic profile. In addition to si......ches for utilizing silicon in medicinal chemistry have been suggested in recent years, focusing on the intrinsic differences......tial for enlarging the chemical space of medicinal chemistry, and provides many options fo...
- 件名Drug Discovery Pharmacology Molecular Medicine
- 参照...nes via Silylamination and Silyl......ation of Aryne Intermediates Gen......f Silicon‐Containing Retinoids: Structure......acophore of Retinobenzoic Acids Using Silyl Functio......ffect-promoted intermolecular si......p>3</sup>)–H amination with dirh......of a Pentacoordinate Germanium Compound Possessing a γ-Lactone a......d a Dative-Bonding Carboxylic Acid Design, synt...
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- 件名Drug Discovery Molecular Medicine
- 参照...one-Class Pim1 Inhibitors Using the Fragment ......ivity cliffs using machine and deep learning methods of increasing complexity Adaptive mining and model building of medicinal chemistry data with a multi-metric pers...
- 並列タイトル等（連結）Miniperspective