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- 要約等... (Volume 1), Clinical Science (V......cuses on the clinical aspects of......search, discussing the role of autophagy in neuropsychiatr......disorders, the cardiovascular, immune, digestive and endocrine systems, as well as tumors, infection, the ki......ts, and presenting the state of the art in autophagy rese......earchers and clinicians alike. I...... students majoring in biology and medicine
- 内容細目... /Sheng Chen, Qinming Zhou, You Ni,......ophagy and Parkinson's Disease / Jiahong Lu, Mingyue Wu, and Zh......d motor neuron diseases / Xiaojie Zhan......disease / Zongbing Hao and Guang......c stroke / Yanlin Zhang, Yongjun......c stroke / Yanlin Zhang and Chun...... and polyglutamine disease / Haigang Ren, Zongbing Hao, and Guan......g Ma Autophagy in neurodevelopme......bao Wu and Weiting Gu Autophagy ......iong Yang and Lin Xu part 2. Autophagy and cardiovascular diseases. Autophagy and......a / Jie Du, Yulin Di, and Wei Zh...... Yan Liu, and Jintao Fu Autophag...... Yan Liu, and Jintao Fu Autophag......clerosis / Junying Miao, Xiaoling Zang, Xiaolin...
- 並列タイトル等（連結）Clinical science
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- 要約等Since its discovery in 1910, histamine has been rega......ant biogenic amines in the medical an......summarizes the information about...... role of histamine in allergic situa......specially focusing on our study with histidine decarboxylase......nockout mouse. In the allergic b......a model, histamine positively controls eosinophilia but not......itivity. Histamine is proved to ......nd respiration in systemic anaph......s but its role in controlling blood pressure is minor. Histamine also plays a role in inducing atherosclerosis in the mouse mode......ly more severe in histamine-deficient mice with diffuse inflammatory infiltrates in the ...
- 件名histamine histidine decarboxylase knockout immunology cardiovascular disease allergy
- 参照Regulation of plasma histamine levels by the......roughput screening system for dynamic monitoring of exocytotic......esicle trafficking in mast cells The Role of Histamine in the Pathophysi......thma and the Clinical Efficacy of Antihistamines in Asthma Therapy Time will tell...
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- 要約等...d psychosocial interventions, including lifestyle cha......mote healthy aging. The text begins with an introduction to the principles of disea......ts who have an interest in healthy aging, the text hig......mote healthy aging. There is an emphasis on maintaining function and preventing disability with increasing age. Common biomedical interventions including exercise, nut...... are addressed in detail. The te......hosocial determinant of healthy aging including, housing, relationships, intimacy, work an...... text then outlines steps that h......mote healthy aging, both for tho...... will be older in the future. Healthy Aging is ...
- 内容細目...ween Healthy Aging and Longevity...... Recent Trends in Longevity; Recent Trends in Onset and Progression of Chronic ...... Recent Trends in Function; Impl...... for Healthy Aging; Healthy Life......t on Healthy Aging; Conclusions;......References; 5: Cardiovascular Health and Healthy Aging; Physiologic Changes with Aging; Vascular; Arterial Stiffening; Endothelial ......rdiac; Changes in Cardiac Morphology; Changes in Cardiac Function; Changes in Aerobic Capacity; Cardiovascular Disease: Disab......ilty; Frailty; Cardiovascular Disease: Risk ...... Cigarette Smoking; Risk Reduction Through Smoking Cessation; Hypertension; Hyp...
- 件名Healthy Aging. Life Expectancy.
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- 要約等...2) is a G protein-coupled recept......ctivated by serine proteases rel......ide ligands administered pharmac......ide expression in the cardiovascular system, particularly within the endotheliu......activity, and link to increased expression of inflammatory cytokines positions PA......ions of tissue inflammation, and injury; and thus,......grade systemic inflammatory condition as inflammatory cytokines released fro......on the changes in vasomotor functions of PAR2 in metabolic syndrome, using an animal mod......ts (SHRSP.ZF). In young SHRSP.ZF......rted that PAR2-induced endotheli......decreased with increasing age and further chron...
- 件名cardiovascular system endothelium metabolic ...
- 参照...ted Receptor 2-Induced Relaxation of Aortas of ...
紙図書
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- 内容細目Experimental models of cardiovascular diseases : overview / J......otake Ishikawa Introduction to c......utational modeling of cardiac el...... Sobie, and Kevin D. Costa Isola......iomyocytes for in vitro studies ......Stefan Hoppler Induction of human induced pluripote......rdiomyocytes using embryoid bodi...... Miki, and Yoshinori Yoshida Measuring cardiomyocyte......d calcium handling in vitro / Przeme......heart function in rats / Makino Watanabe and ...... potential mapping in acute models o......ia-reperfusion injury : probing the arrhythmo......nslocator protein / Zeki Ilkan, Benjamin Strauss, Chiar......diac tissue engineering models of inherited and...
- 件名Cardiovascular system--Diseases--Mathematical models. Cardiovascular Diseases. Models, Cardiovascular. Disease Models, Animal.
- 資料の内容に関する注記...methodological information on establishing reliable and ......ntal models of cardiovascular diseases. Chapters deta......oratories focusing on cardiovascular research, leading to novel discoveries in cardiac biolog......aches. Written in the highly suc......essful Methods in Molecular Biol......rmat, chapters include introductions to ......on troubleshooting and avoiding known pitfall......tative and cutting-edge, Experim......ntal Models of Cardiovascular Disease: Metho......essful results in the further study of this vit...
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- 要約等...d Research and Interactions prov......kground needed in biophysics and......asizes the growing interrelatedness ......stry, and acquaints one with exp......of both disciplines. This book a......rmous advances in biochemistry, particularly in the areas of s......biology and bioinformatics, by providing a solid bioch......that is rooted in chemistry. Topics include scientific integrity and ethics in the field; clinical translational research in cancer, diabetes, and cardiovascular disease; emerging drugs to trea......rodegenerative diseases; swine, avian, and h......se of big data in artificial knowledge in the field; bioinformatic insi...
- 内容細目...tors of checkpoint kinase for cancer ......gonists : emerging drugs to trea......rodegenerative diseases / Vinod G. Ugale, Ra......e scaffold bearing compounds as ......ymatic targets inhibitors against various fila......ife / Anamika Singh and Rajeev Singh Bioinformatics : progress, trends, and challenges / Chin Kang Chen, Her......d Leu Fang-Yie Insights into the natural hypoglycemic principles : translating traditional m......rget knowledge into modern therapy / Satyaendra...
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- 要約等...e factor of retinopathy of prema......ve diabetic retinopathy, and wet......important role in pathological a......eat the ocular diseases that are drive...... of VEGF signaling, including impairments of normal retinal vascular growth and retinal function, we......onstrated that inhibitors of the......rget of rapamycin (mTOR) target proliferating endothelial cells within the retinal vasculature.......ntial of targeting the mTOR pathway to treat pa...
- 件名mammalian target of rapamycin pathological angiogenesis retina vascular endothelial growth ...
- 参照... valproic acid in a mouse model of oxygen-induced retinopathy Hyperglycemia-induced VEGF and ROS production in retinal cells is inhibited by the mTOR inhibitor, rapamycin
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- 要約等"Cardiovascular disease and re......oncommunicable diseases were once cons...... only wealthy, industrialized na......ank as the leading cause of deat......percent--occur in low- and middle-income countries.......blem, the U.S. Institute of Medicine formed a comm...... focus action. In this special issue, Promoting Cardiovascular Health Worldwi......authorities on cardiovascular disease elaborate on the Institute of Medicine's 12 recommen......s that are working effectively o......lect on global progress made--and define a way forward"--Publisher's ...
- 内容細目Introduction: promoting global cardiovascular health: the Institute of Medicine recommendations / Valentin Fuster, Rajesh......ry Paton, K. Srinath Reddy and K......te for chronic diseases as a funding priority: Funding the fight against chronic diseases / Valentin Fuster Recomme...... national coordination for chronic diseases: Kenyans come together against chronic diseases / Gerald Yonga......ies to promote cardiovascular health: how po......rs can advance cardiovascular health / Sonia......ll, Jessica Levings, Andrea Neim......ommendation 5: include chronic diseases in health systems strengthening: Echoing the lessons of HIV ...
- 件名Cardiovascular system--Diseases--Prevention. Cardiovascular Diseases--prevention & ......ethods. Developing Countries.
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- 要約等...ix metalloproteinases and cathepsins, in the normal and......ased heart. During the past two ......des, matricryptins have been defined as fragments......ties have been initially identif......and clarified, including anti-angiogen......hus, matricryptins are expected ......nd thus widely investigated. Alt......n of matricryptins in fields other t......some matricryptins have been rec......iogenic effect in heart. This re......ived matricryptins, including arresten, canstatin, tumstatin, endostatin and endorepellin, during cardiac diseases leading to heart fail......and myocardial infarction.</p>
- 件名cardiac hypertrophy cardiomyocyte fibroblast matricryptin myocardial infarction myofibroblast
- 参照...ment of tumstatin, stimulates pr......n of Akt signaling pathway T3 pe......ment of tumstatin, inhibits H 2 O 2 -induced apoptosis in H9c2 cardiomyoblasts Endostatin is protective against monocrotaline-induced right hea......se through the inhibition of T-t...... Ca2+ channels in the heart Endorepellin-evoked Autopha......esten, an α1β1 integrin-dependent coll......d from Endostatin Ameliorates Or......eous wound healing, while overex......of its endostatin domain leads to delayed healing RETRACTED ARTICLE: Inhibitory Effect......resten on bFGF-Induced Prolifera......ix Metalloproteinase-2 Activation in Mouse Retinal Endothelial Cel...
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- 要約等... reports regarding femoral arter......etes. Here, we investigated whet......e to noradrenaline in femoral arteri......s would change in type 2 diabeti......demia, and hypoinsulinemia compared t......rat. Noradrenaline-induced contraction was increased in femoral arteries in OLETF rats com......whereas serotonin- or phenylephrine-induced contracti......als. Acetylcholine- and sodium nitroprusside-induced relaxatio......ll relaxations in femoral arteries induced by clonidine and isoprenaline were obtained in LETO but not O......oup. Noradrenaline-induced contracti......up>-nitro-L-arginine (L-NNA), a ni......synthase (NOS) inhibitor, and the between-group...
- 参照Mechanisms underlying the methylglyoxal-induced enhancement of uridine diphosphate-m......ed contraction in rat femoral ar......racellular Uridine Nucleotides-Induced Contractions Were Increased in Femoral Arteri......to Nucleotides in Femoral Arteries of OLETF and...
- 参照Epigallocatechin gallate attenuates ET-1-induced contraction in carotid artery......terial disease in diabetes—a rev......Vasorelaxation in Zucker Diabeti......erived Factors in Mesenteric Art......terial Disease in Patients with ......Mellitus Screening for periphera......ankle‐brachial index in newly diagnose......tile responses in spontaneously ......roducts Serotonin induces vasoconst......e cell‐rich neointima through 5‐hydroxytryptamine2A receptor in rabbit femoral arteries Increased oxidati......f contractions in arteries from ...... rats Pravastatin normalizes ET-1-induced contraction in the aorta of type 2 diabetic ...
紙図書
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- 内容細目Introduction to s......of sumoylation in mRNA processing and metabolis......UMO and chromatin remodeling / David Wotto......berton, Jacqueline Merrill-Schoo......ctions of SUMO in the maintenance of geno......la Zilio, Karolin Eifler-Olivi, ......Jorrit M. Enserink The molecular interface between......UMO and ubiquitin systems / Jeff L. Staudinger SUMO and nu......nson, Jorge A. Iñiguez-lluhí, ...... roles of SUMO in metabolic regu......n / Elena Kamynina, Patrick J. S......e SUMO pathway in mitosis / Deba......ry Dasso Wrestling with chromoso......les of SUMO during meiosis / Ama...... Nottke, Hyun-Min Kim, Monica P. Colaiácovo Su...
- ジャンル・形式用語Fulltext. Internet Resources.
- 件名...fication. Proteins--Synthesis. Ubiquitin. Small Ubiquitin-Related Modifier Proteins--physiology. Biochemical Phe...
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- 要約等... aspects of ageing research: nut......epigenetic imprints such as DNA ......d by these two interventions. Th...... helps to illuminate the underlying mechanisms of anti-ageing interventions, as ageing and disease are predominately epigeneti......s as: how anti-inflammatory acti......ardation of ageing and age-related diseases (Chapter 3); e......ive components in bone health (C......ie restriction in nonhuman prima......y the National Institute on Ageing."--Cover.
- 内容細目Nutritional epigenetics and aging Dietary restr......igenetics of aging and longevity Anti-inflammatory acti......tardation of aging and age-related diseases Hormonal influence and modulation in aging Epigenetic mo......of redx signalling Sarcopenia and its intervention The ......ive components in bone health Nutritional interventions for cardiovascular aging and age-related cardiovascular diseases Calorie restri......ion mimetics : progress and potential ......ie restriction in non-human prim......y the National Institute on Aging : the first decade.
- 件名Medicine. Geriatrics. ......cation of proteins. Cytology. Aging--Research. Aging--genetics. Epigenomics. Exer...
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- 要約等Medicinal plants and t......d products remain as an indispensable sou......d therapeutics including wide availabi......reports from clinical studies testifying to the effica......safety of medicinal plants and phytochemicals in ameliorating several human diseases. A plethora of......hanisms underlying the health be......of herbal medicines. Nevertheles......n of bioactive ingredients, stan......ducts and drug interactions remain to be further studied. In this book, we ......rs on the medicinal properties a......action of medicinal plants, plant species and p...
- 内容細目The effect of curcumin supplementatio...... wave velocity in patients with ......ized, double-blind, placebo-cont...... Role of curcumin in regulating long noncoding RNA expression in cancer / Abolfazl Amini [and 7 others......ffect of curcumin phytosome on t......se: a double-blind, randomized, ......fects of curcumin phytosomes against high-fat diet-induced atheroscl......[and 8 others] Intravenous curcumin mitigates atherosclerosis progression in cholesterol-fe...... role of curcumin in gastrointestinal cancers / Me...... others] Curcumin can bind and interact with CRP: an in silico study /......ities of curcuminoids and difluorinated curcumi...
- 件名...y Plants, Medicinal Phytochemicals Phytotherapy...
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- 要約等... and how it is instrumental in advancing the field of disease modeling and cell tran......ation. By focusing on major huma......zes the major findings in the field of h...... our understanding of stem cells......epigenetic editing, that will be instrumental in the future of ......n disease modeling and treatment. In base of the li......ase models and in front of the u...... necessity of finding therapeutical interventions for...... theoretically inexhaustible and......cell subtype. Since Professor Shinya Yamanaka des......, 10 years ago in his seminal paper, that ......eprogrammed to inducible stem ce......just by expressing four transcription factors, ...
- 件名Human genetics Molecular biology Stem cells Stem Cells Human Genetics Molecular Medicine
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- 要約等...rtension, offering new insights into the developm....... It describes in detail the mol......lar mechanisms involved in the developmen......teriosus, covering a range of to......s and cellular interactions, as ......s stem cell engineering technologies.......ecent advances in our understanding of the molecu......scientists and investigators interested in the latest findings on the origins of congenital......ture therapies involving pulmonary circulation/hypert...
- 内容細目...nd Notch Signaling / Morimoto, M......ll Progenitors in Pulmonary Hype......y of Prostacyclin Mimetics: Impl......mal Transition in Pulmonary Hype...... Roles of Tbx4 in the Lung Mesen......nsgenic Mouse Line Revealing the Developme...... / Ishizaki, Reina (et al.) Role......Cell Antigen-1 in the Pulmonary ......scular Disease in Bronchopulmona......d by Hyperoxia in Newborn Mice /......ehiko (et al.) Involvement of CX......and Stem Cells in a Rat Model of......sion / Zhang, Tingting (et al.) Ca2+......Signal Through Inositol Trisphos...... Receptors for Cardiovascular Development an......ry Circulation in Congenital Heart Disease / Ha...
- ジャンル・形式用語Conference papers and proceedings. Congress.
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- 内容細目Basic mechanisms underlying induction, progression, and resolu......ion of chronic inflammation Prostaglandins in chronic inflammation Tomo......sms of chronic inflammation-asso......4A and chronic inflammation Dais......oh 著 MicroRNAs in chronic inflammation Y. I......section of autoinflammatory synd......ogy of chronic inflammation-associated signalling pathways Reiy...... Lipid signals in the resolution of inflammation Mako......ion of chronic inflammation by c......ively regulate inflammatory resp......raishi ほか著 Imaging analyses of chronic inflammation Macr......ge dynamics during bone resorption and chronic inflammation Junichi Kikuta, Kei...
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- 要約等...drugs for treating numerous diseases. Most present-day medicines are derived ...... compounds continue to offer lim......ry of new medicines. While diffe......avonoids, saponins and alkaloids......re currently being explored, the...... be understood in detail. This book is divided into 2 volumes an......ffers detailed information on pl......ive compounds, including recent research findings. Volume 1, "...... community wishing to further ex......e various medicinal plants and t......and scientists involved in plant product research, and f...
- 内容細目1.5 Orientin Against Colon Cancer in Different Ways......e, and Polyp's Incidence 1.5.2 L......iotic Metabolizing Enzymes 1.5.4.......5.6 Mast Cell Infiltration 1.5.......1.5.8 NF-B and Inflammatory Cytokine Expression 1.5.9 Pro-Inflammatory Enzy...... Flavonoids Against Colorectal C...... of Action 2.1 Introduction Intro Foreword Pr......ditor 1: Orientin: A C-Glycosyl ......tal Cancer 1.1 Introduction 1.2 ......avonoid's Role in Cancer Prevent.......3 About Orientin 1.3.1 Chemistr......Colorectal Carcinogenesis 1.4.1 ......ectal Adenocarcinoma) Cell Line 1.4.2 Chemically Induced Animal Mo......ls 1.4.2.1 DMH-Induced Experimental Colon Carci...
- 件名...ry. Plant breeding.
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- 内容細目Part I. Introduction – Ov......gnitive and brain aging / Stephanie L......s – Effects of cardiovascular disease and re......tes and the brain / Olga Neyman,......w, Daniel E. Weiner – Cognitive impairment in liver disease ......sh Pantham, Kevin D. Mullen – Pu......Neurocognition in menopause and ......itive function in mood and anxie...... Snyder, Benjamin L. Hankin – Neuropsychol......ifer J. Vasterling, Gabriel S. W......lt – Cognition in schizophrenia ......isorders / Martin Strassnig, Phi......ects on the brain and neuropsych......chael K. Scrullin – Autism spectrum disorders in adults / Charo......sch, James L. Findon, Declan G. Murphy – Cognit...
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- 並列タイトル等（連結）Progress in cerebral and cardiovascular diseases prevention, and its future di...
- 並列タイトル等Progress in cerebral and cardiovascular diseases prevention, and its future di...