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- 要約等Medicinal plants and t......d products remain as an indispensable sou......d therapeutics including wide availabi......reports from clinical studies testifying to the effica......safety of medicinal plants and phytochemicals in ameliorating several human......hanisms underlying the health be......of herbal medicines. Nevertheles......n of bioactive ingredients, stan......ducts and drug interactions remain to be further studied. In this book, we ......rs on the medicinal properties a......action of medicinal plants, plant species and p...
- 内容細目The effect of curcumin supplementatio...... wave velocity in patients with ......ized, double-blind, placebo-cont...... Role of curcumin in regulating long noncoding RNA expression in cancer / Abolfazl Amini [and 7 others......ffect of curcumin phytosome on t......se: a double-blind, randomized, ......fects of curcumin phytosomes against high-fat diet-induced atheroscl......[and 8 others] Intravenous curcumin mitigates athe......is progression in cholesterol-fe...... role of curcumin in gastrointestinal cancers / Me...... others] Curcumin can bind and interact with CRP: an in silico study / Neda S......ities of curcuminoids and difluorinated curcumi...
- 件名...y Plants, Medicinal Phytochemicals Phytotherapy...
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- 並列タイトル等（連結）Pharmacology from the viewpoint of medical ed......ion curriculum integration : Pos......velopment from in vivo to in silico in pharmacology training
- 並列タイトル等Pharmacology from the viewpoint of medical ed......ion curriculum integration : Pos......velopment from in vivo to in silico in pharmacology training
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- 要約等...(homology modeling, molecular docking, molecular dynamics, protein-protein interaction netwo......rmacophore mapping, quantitative......design for ranking and prioritiz......date molecules in search of effe......nt strategy against coronaviruses. Beginning with an introductory sect......es coronavirus interactions with......y and COVID-19 in particular, th...... book then continues with sectio...... as well as online tools and dat......or the Methods in Pharmacology and Toxicology......ries, chapters include the kind of practical ......uality results in the lab. Compr......ve and timely, In Silico Modeling of Drugs Agai...
- 件名Drug development--Methodology Coronavirus infections--Treatment Coronavirus infections--Treatment.
- 関連情報Methods in pharmacology and toxicology Springer protocols
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- 要約等...ome an outstanding issue in the process of......acological testing of the selected compound in high doses in tests directed at indications other than the intended indication of the......ed by pharmacokinetic studies, which were mainly aimed at confirming of a suitable......h however gave information on ch......l and pharmacokinetic studies we......ess of studies in clinical pharmacology and clinical trails. Bu......e success rate in the pharmaceutical industry and the introduction of n......a new compound increased, sometimes exceeding the patent pr......efore adopted, involving the following changes: - Parallel instead ...
- 内容細目... Resonance Imaging in Pharmaceutical...... / Paul D. Hockings Oncology Pharmacology / Jason H. Gil......n-Pierre Valentin Zebrafish in Drug Discovery......ons for Safety Pharmacology / Björn Lemme......v Biomaterials in Their Role in Creating New Approache......of Drugs, Proteins, Nucleic Acid......ogy and Safety Pharmacology / A. Michael B......rt 2. Pharmacokinetics. Safety Pharmacokinetics: Introduction / Jo......as Absorption: In Vitro Tests Ce...... Based / Katharina Mertsch Non C......nn Absorption: In Vivo Tests (Ra......s: RIA/EIA / Heinz Jürgen Skrzi...... Assays Toxicokinetics / Karl-Heinz Lehr Distribution In Vitro T...
- 件名Pharmacology, Experimental.......gn. Drugs--Testing. Chemistry, P......aluation, Preclinical. Pharmacokinetics. Pharmaco......ents--Essais cliniques.
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- 件名Pharmacology
- 参照A study on attempt for determination of permeation kinetics of coumarin at lipid bilay......liposomes by using capillary ele......s of Plant Origin: A Review of Phytochemicals w...
- 著者標目Florent Di Meo Gabin Fabre Karel Be......i Ossman Benjamin Chantemargue Markéta Paloncýo...
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- 要約等...h muscle (DSM) instability is a ......jor cause of urinary bladder ove......tional anticholinergic drugs¸ re......chers are focusing on novel drug......ity. Understanding the drug effe......re our overarching objective is ......ects of nifedipine and mibefradi......circuit consisting of a membrane......ance connected in parallel with ......ances representing two voltage g......channel and an inward rectifying cation channe......del for nifedipine and mibefradi......ted by multiplying the maximal c......nel with a scaling factor betwee......</p><p>The resting membrane pote...... 50mV by balancing the ion channel conductances...
- 件名In silico pharmacological assessment Ac...
- 著者標目Mahapatra Chitaranjan Manchanda Rohit Brain Kl
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- 要約等...h muscle (DSM) instability is a ......jor cause of urinary bladder ove......tional anticholinergic drugs¸ re......chers are focusing on novel drug......ity. Understanding the drug effe......re our overarching objective is ......ects of nifedipine and mibefradi......circuit consisting of a membrane......ance connected in parallel with ......ances representing two voltage g......channel and an inward rectifying cation channe......del for nifedipine and mibefradi......ted by multiplying the maximal c......nel with a scaling factor betwee......</p><p>The resting membrane pote...... 50mV by balancing the ion channel conductances...
- 件名Detrusor smooth muscle Action potential In silico pharmacological assessment
- イベントの日付、場所World Congress of Basic and Clinical Pharmacology
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- 参照Active learning for computati......ic Active Learning
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インターネットで読める全国の図書館
- 並列タイトル等（連結）Pharmacology from the viewpoint of medical ed......ion curriculum integration: Poss......velopment from in vivo to in silico in pharmacology training
- 並列タイトル等Pharmacology from the viewpoint of medical ed......ion curriculum integration: Poss......velopment from in vivo to in silico in pharmacology training
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国立国会図書館
- 内容細目In vitro selectio......es and the origins of biochemica......n, simulations in silico, and concepts for in vitro selectio...... and cofactors in aptamer evolut......iotics / Christina Lorenz and Re......tamers to proteins / Shahid M. N......al metabolite-binding RNAs controlling gene expressi......ecules : tools in organic chemis...... McManus, and Yingfu Li In vivo and in vitro target v...... David M. Epstein Intramers for protein function analy......d Andrew D. Ellington Conversion of aptamers into small-molecu......ligands for affinity chromatogra......ons / Eric Peyrin Aptamers for in vivo imaging / Sandra Borkowski and Ludge...
- 一般注記...r biographical information http: //www.loc.gov/...
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- 要約等...tatively determine the phytochem......ational study, including molecular docking, and ADME/T (......esic, and anti-inflammatory acti......of this plant. In the gas chroma......ocumented as being bioactive based on their binding affinities. These se...... molecular docking studies that ......uated to determine their drug-li......yed favorable binding affinities to potass......, human serotonin receptor, cycl......man peroxiredoxin 5 receptor proteins. Phytol aceta......nds identified in E. papillosum ......ng predictive binding affinities towards t......e human serotonin receptor. Furt......a significant binding affinity for the KcsA pot...
- 件名...Molecular Medicine Drug Discovery Pharmaceutica...
- 参照... Molecular Docking, Molecular Dy......ons & Pharmacokinetic Predictions of Some Methy...
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- 要約等...sed to be used in biomedicine, but only pol......sed typically. In this study, we...... units) consisting of 3-hydroxyb......cal PHA consisting of 4-hydroxyb......alerate. According to our simula......otoxicity, carcinogenicity or mu......substrates nor inhibitors of the cytochromes involved in the xenobiotic......nsidered to be inhibitors of the......, and OATP1B3. In addition, they......d corrosion, skin irritation and have a low ant...
- 件名Biomedical Engineering Histology Bioengineering Biotechnology
- 参照...te Oligomers Using Recombinant Escherichia coli
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- 件名Library and Information Scien......al Chemical Engineering General Chemistry
- 著者標目Jordi Mestres Lidia Martín-Couce Elisabet Gregori-Puigja...
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- 著者標目EKINS S
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- 要約等<jats:p>Data in the biological......hemical, and clinical domains are accumulating at ever‐increasing rates and hav......accelerate and inform drug development in new ways. Chal......nities now lie in developing analytic tool......rogeneous data into testable hyp......and actionable insights. This is...... computational pharmacology, which uses <jats:italic>in silico</jats:italic> ......ems, which can in turn improve clinical use, avoid......ents. One exciting application o...... computational pharmacology is drug repurposing—finding new uses for existing drugs. Already yielding many promising candidates, t......ent techniques in computational pharmacology an...
- 件名Biochemistry, Genetics and Molecular Biology (miscellaneous) Medicine (miscellaneous)
- 参照An integrative approach using real-world da......c uses of existing drugs
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- 要約等...mited accuracy in clinical risk predi...... also facilitating translation t......Key challenges include consideration of inter-cellular variability in drug responses and integration of co......mental methods in safety pharmacology. Our aim is to......the ability of in silico drug trials in populations of......s to predict clinical risk of drug-induced arrhythmi......on ion channel information. </p>......as conducted using the Virtual A...... framework for in silico drug trials in populations of......hodology: starting from the O'Ha......tential models in agreement with......rimental recordings was constructed, accounting...
- 件名Torsade de Pointes safety pharmacology in silico drug trials
- 著者標目Bueno-Orovio Alfonso Passini Elisa Britton Oliver J Rodri...
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- 要約等...mited accuracy in clinical risk predi...... also facilitating translation t......Key challenges include consideration of inter-cellular variability in drug responses and integration of co......mental methods in safety pharmacology. Our aim is to......the ability of in silico drug trials in populations of......s to predict clinical risk of drug-induced arrhythmi......on ion channel information. </p>......as conducted using the Virtual A...... framework for in silico drug trials in populations of......hodology: starting from the O'Ha......tential models in agreement with......rimental recordings was constructed, accounting...
- 件名in silico drug trials safety pharmacology Torsade de Pointes
- イベントの日付、場所World Congress of Basic and Clinical Pharmacology
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- 件名Pharmacology
- 参照Association between use of Qingfei Paidu Tang and mortality in hospitalized patients with CO...
- 著者標目... Liu Chen Bai Yingchao Wang Xiao......ang Rui Guo Siying Wu Jianxun Wang Elaine Leung Hang Chang Peng Li Tie...