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- 要約等...ch as 8-oxoguanine（ 8-oxoG）, accumulate in nuclear and mi......ial genomes during aging, and such acc......o dramatically increase in patient brains with Parkinson’s disease（ ......with three distinct enzymes, MTH......es oxidized purine nucleoside tr......cosylases excising 8-oxoG opposite cytosine and adenine opposite 8-oxoG in DNA, respectiv......a signifi cant increase in 8-oxoG in cellular DNA a......OGG1 and MUTYH in PD and AD brains, suggesting that the buil......ldup of 8-oxoG in either nuclear......hrough two distinct pathways, an......ed nucleotides in nucleotide poo......e exhibited an increased buildup of 8-oxoG in s...
- 件名8-oxoguanine MTH1 OGG1 MUTYH
- 著者標目Yusaku Nakabeppu Zijing Sheng Sugako Oka
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- 要約等Leptin is well known to be involved in the inhibition of feeding, thermogenesi......and neuroendocrine functions thr......receptors. Leptin facilitated th......e transmitters in the hippocampa......f Ca2+/calmodulin protein kinase II （CaMK II......re facilitated in the CA1 neuron......o spatial learning and memory wa......mproved by leptin in vivo applications. Orexin-A produced by ......sitive neurons in the lateral hy......nd released during food intake facilitates feeding. Orexin-A suppressed L...... without affecting the presynapt......rmance on learning and memory wa......ggest that leptin and orexin signalings in the ...
- 件名Leptin Orexin CaMK 2 phosphorylation Facilitation and impairment of learning and memory in rodents
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- 要約等...ctive angiotensin-converting enzyme （ACE） inhibitors may protect against dementia bey......nism（s） underlying these improvements in cognitive function remains unclear. We measured the brain peptide levels in rat treated wi......r 3 weeks by using surface-enhan......-MS）. Two protein chip arrays we......peptide profi ling： one with a s......hanger. Comparing with control group, 15 mass ...
- 件名ACE inhibitors captopril memory
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- 要約等...ial for catalyzing the Fenton re......amount of iron in the brain is strictly controlled. In this study we ...... （Fe（II）） iron in the adult female rat brain by light and e......s much less dominant than Fe（III）, the brain contained iron in both forms. Am......lements of the brain, oligodendrocy......cally most prominent and heavily iron-storing cells. Perica...... Large neurons involved in the motor syst...... Fe（II） were mainly localized in lysosomes, and occasionally in the cytosol an......hown on the luminal membrane of ......um. With advancing age, both Fe（......ore numerously into oligodendrocytes. 弘前医学. 61(...
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- 要約等...amyloid ß protein in Alzheimer’s Di......verview of the research fi ndings that have ma......Aß42, a compelling therapeutic t......r AD that is being pursued by vi...... who are at imminent risk for AD. In the last part ......ecent evidence indicating that the meas...... Aß40 and Aß42 in plasma may be ......ul for identifying those normal subjects who wi...
- 著者標目Steven Younkin
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- 要約等...patial changes in microvascular ......regulation may involve communica......or glial cells in either rapid o......slow conduits. In the present st...... we report distinct diff erences......erial networks in cortical surface and in intracortical tissue regions in response to se......stimulation. Using confocal and ......ion laser scanning fluorescence ......cular networks in the somatosens...... rats. Changes in lumen diameter......ulus-dependent increase in the lumen diam......erial networks in both cortical ......-stimulus baseline diameter. Fur......l vasodilation increased in a stimulus-dep......r. The results indicate that global vasodilatio...
- 件名two-photon microscopy in vivo optical imaging neurovascular coupling functional brain mapping
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- 要約等Antibodies to amyloid β protein（ Aβ） are prese......r after Aß vaccine therapy in human plasma. ......larify their clinical role, we examined plasma sampl......mal controls using the tissue am......R was revealed in AD （45%） and a......e was observed in the MMS score ...... even detected in samples from y...... Aβ40/42 ratio increased, and Aβ......ntly decreased in plasma from AD...... and TAPIR grading. Thus an immu......rred naturally in humans without...... the Aβ burden in the brain. Clarifi cation of the mechan...
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- 要約等...cognition proteins （PGRPs） are p......conserved from insects to humans......se activities. Insect PGRPs cons......ay （PGRPLC）and induction of auto......ute to the elimination of bacter......ammalian PGRPs in bacterial infection remains unclear. In this study, we......ue of PGRP-SA, in bacterial infection. The recombinant protein was produced in Escherichia co......production. We investigated the role of PGRP-S in infection with Li...... that can grow intracellularly. The administration of recombinant PGRP-S befo...... monocytogenes infection decreas......er of bacteria in the organs of infected mice. Wh......cterial number increased. The levels of proinfl...
- 件名PGRP-S Listeria monocytogenes cytokine innate immunity
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- 要約等...hage （SAH） remains a disease without any definitive treatment options. Research, to date, has ......ncept of Early Brain Injury （EBI）, a p......y help to explain the complex pa......hysiology seen in patients after......nts that occur in the brain within the first seve......ay play a role in the etiology o......nt a key event in the developmen......ical Deficit （DIND） after subara......uired to determine the pathophys......EBI and to examine its role as a......vasospasm and DIND. 弘前医学. 61(Suppl.), 2010, p.S...
- 件名Subarachnoid Hemorrhage Early Brain Injury Vasospasm Delayed Ischemi...
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- 要約等Glucose transport activity in mammalian cell......olution, measuring glucose uptake in single, living cells was dif......-diazol-4-yl）amino]-2-deoxy-D-gl......glucose uptake in live cells. Indeed, the uptak......orters （GLUTs） in a concentratio......ndent manner. Kinetic analysis r......glucose, found in pancreatic isl......hod can be combined with Ca2+ imaging and subsequen......sed for monitoring glucose uptake into a wide varie......ammalian cells including astrocytes an...... it has been pointed out that 2-......e procedures, since the fl uorescence intensity is an a......trary measure. In addition, temporal changes in...
- 件名2-NBDG 2-NBDLG GLUTs Glucose Uptake L-Glucosamine
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- 要約等The mechanism regulating cerebral bloo......fl ow （CBF） during brain function （neurovascular coupling）has been widely investigated in animals under ......ovascular coupling studies in awake-behaving mice. Male C5......L/6J mice were initially anesthe......th isofl urane in preparation for attaching the study app......d regional CBF in the somatosens......sia was discontinued during recovery, whi......or 20 sec） was induced at either...... the LDF recording site. During the experimen......igns of struggling against the head restraint. The intensity of baseline CBF was highe......anesthesia, an increase in CBF （34 ± 18%） was o...
- 件名laser-Doppler flowmetry Functional brain imaging whisker stimulation behavior...
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- 要約等Cystatin C （CC）, a cysteine protease inhibitor involved in protein degradation, i......a marker of Bunina bodies in lower motor neurons in amyotrophic la......immunoreactive inclusions are al......lization of CC in ALS motor neur......ith or without inclusions is uncertain. Recently, we ......ed moderate to intense immunoreactivity for CC in controls and t......rely decreased in anterior horn cells in ALS. The propo......e neurons contained Bunina bodies or not. In contrast, the ......ntly reduced owing to the presence of TDP-43 inclusions. These fi ndings suggest that......tion of TDP-43 inclusions, but not of Bunina bodies, reduces the content ...
- 件名Amyotrophic lateral sclerosis Immunohistochemistry Bunina body Cystatin C TDP-43
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- 要約等...t phenotype of brain aging. Understanding the molecular......hanisms underlying AMI is import......ientific viewpoint but also for ......lead to developing drugs to comb......rom disruption in specifi c memory process. In Drosophila, me......uired after a single olfactory conditioning paradigm has three distinct phases: shor......and longer-lasting anesthesia-re......r components. Since amnesiac enc......the cAMP signaling pathway in AMI in Drosophila, a fi nding consistent wi...... models of AMI in mammals. In fact, hypomorphic mutations in PKA catalytic ...... As cAMP signaling is an essential signaling for learning and memory, the...
- 著者標目Daisuke Yamazaki Junjiro Horiuchi Minoru Saitoe
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- 要約等...ar gene, Dec2, in 1997 and 2000,......c1 mRNA levels in chondrocytes in vitro and rat liver in vivo. We then ......are implicated in the circadian ......c1 and/or Dec2 in most tissues, including the suprachia......regulatory and interlocked feedb......of these genes indicate that Dec......ec2 play roles in the phase shift and maintenance of accu......t clock genes, including Dec, are involved in the pathology ......diseases and aging. 弘前医学. 61(Suppl.), 2010, p.S...
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- 要約等...occal enterotoxins （SEs） are the......nism of emesis induced by SEs and no vaccine that prevents SE-induced emesis ha......-type SEA. SEA-induced emesis wa......ssay. Neutralizing activities of...... were analyzed in vitro and in vivo. Results....... but still retained its immunolo......D227A strongly induced specifi c...... protection against SEA-induced emesis. T......hrews markedly inhibited the SEA-induced prolifera......blated the SEA-induced vomiting in the animals. C......ggest that vaccination with SEAD...... protection against SEAinduced emesis. T......ight be useful in the prevention......cal food poisoning 弘前医学. 61(Suppl.), 2010, p.S2...
- 件名staphylococcal enterotoxin immunization emesis house mus...
- 著者標目Dong-Liang Hu Katsuhiko Omoe Hiroshi Sashinami
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- 要約等Painful diabetic ne......steroidal anti-infl ammatory dru......ow those producing disruptive side eff ects. In the present study, we examined the effect o......modulate the pain pathway, on me......ical allodynia in streptozotocin（ STZ）-induced diabetic ......signifi cantly increase 5 days after STZ injection and was maintained for more than 14 days. Intrathecal administration of P2......S and TNP-ATP） inhibited the mec......ical allodynia in diabetic mice....... P2X receptors in DRG in diabetic mice ......ere measured using quantitative ......signifi cantly increased in diabetic mice ......days after the intravenous injection of STZ. Fu...
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- 要約等... such as curcumin and neurite outgrowth-promoting prostaglandins （NEPPs）, have......rite outgrowth in the presence o......th factor （NGF）in PC12 cells. Ho......s function by binding to the cell surface tyrosine kinase receptor, T......nate （6-HITC）, inactivates PTP1B causing sustained phosphorylat......TrkA and promoting neural diff e......hat is a major ingredient in the herb rosem......ells by activating the redox-sen......aused a marked induction of p62/......mportant signaling scaff old protein for NGF signaling. Unexpectedly......dependent and -independent mechanisms. 弘前医学. 61...
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- 要約等...important goal in the treatment ......cular diseases in order to avoid......mprove devastating long-term seq......h and survival in the central ne......development of brain edema during cerebral isch......ia/reperfusion injury in the CNS. Edaravone, a brain-penetrant, fre......important role in the coordinated expressions of stress-inducible genes. ...... various genes involved in the regulation......apeutic target in brain injury. This revi......a natural Nrf2-inducer as neurop......tective agents in human astrocytes, particularl...
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- 要約等By analyzing late onset Al......disease （LOAD） in a genome wide ......ies and evaluating the 25 SNPs w......ic association in 4 additional s......894） on Xq21.3 in PCDH11X that i......ated with LOAD in American Cauca......c regression using sex as a cova......of 3.9 x 10-12 in the combined series. Odds......gotes for the minor allele were ......ional variants in PCDH11X for as...... is not surprising since these two variants are in near perfect linkage disequilib.......99）, and the minor allele of th......, rs2573905 is in a sequence tha...... 100bp, suggesting a possible fu......or this SNP. Joint analysis of APOE and rs25739...
- 著者標目Minerva M. Carrasquillo Fanggeng ...
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- 要約等Clumping factor A （ClfA） is an adhesin of Staphylococ......） compose fi brinogen binding domain. It was report......important role in the protective eff ects. In this study, we investigated the role of IL-17 in the protective...... ClfA40-559 against S. aureus infection. Mice ......terial numbers in the organs and......fA40-559. Cytokine production an......RNA expression in the spleens an......ells was determined by ELISA and......terial numbers in the organs were reduced in the mice immun......59. ClfA40-559 induced IL-23p19 ......-12 production in DC2.4 and RAW2......RNA expression in the spleen cel......naïve mice was induced. In the spleen cells of ...
- 件名Staphylococcus aureus Clumping factor A Immunization IL-17 ...