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- 要約等Aging is an inevitable part o......e, and is becoming a worldwide s......e fact that an increasing proportion of individuals in the advanced a......lity of developing age-related disorders. New therapeut......ches are still in need to decrea...... such diseases in this aging society. Advances in 'omic technolo...... our understanding of diseases in multiple medic......oped that emerging hits from the...... further screening as potential ......ug targets for increasing the human healthspan in line with the life......an, which will in turn lead to n......pharmaceutical industry.This new......reviews describing studies which have resulted ...
- 内容細目...anagement of Aging Alzheimer's D......tion of Stress in 17,414 Critica......Gender and Working Conditions Targeting Age-related N......ssue the Fountain of Youth? The ......se Atem Cell Aging on Metabolic Homeostasis, L......Identification in Psychiatric an......rodegenerative Disorders Index
- 件名Drug targeting Drug targeting.
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- 内容細目Obstructive sleep apnea in adults : epidemiology, clinical presentati......atment options Inflammation, oxi......botic activity in adults with ob......ve sleep apnea Metabolic disorders associated wit......ve sleep apnea in adults Endothe......al dysfunction in adults with ob......onomic changes in adults with ob......Cardiovascular disorders associated with obstructive s...
- 件名...s. Metabolism--Disorders. Sleep Apnea, ......ses--etiology. Metabolic Diseases--etiology.
- タイトル標目Advances in cardiology ; v. 46. 0065-2326
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- 要約等...f reviews focusing on Druggable Lipid Signaling Pathways. It ......es researchers in both academic institutions and industry as well ......of lipid signaling and future di......iscovery targeting lipid signaling pathways. Thi......des 9 pathways including acyltransfera......atty acids, sphingolipids, lysop......ids, endocannabinoids, phosphoinositides, and l......ch lipid signaling pathway that ......ge of diseases including neurological ......ic diseases, pain, metabolic syndromes, car......ses, fibrosis, inflammation, etc......ny drugs targeting lipid signaling have been clinically used. Dr......also discussed in each chapter, which includes ...
- タイトル標目Advances in experimental medicine and biology ; v. 1274
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- 要約等Histamine H<sub>3</sub>......lease of histamine and other neu......s such as norepinephrine, dopamine, and acetylcholine in the central ne......ction of histaminergic neurons f......ly distributed in the CNS and ar......logical roles, including regulation of feeding, arousal, cognition, pain, and endocrine systems. To f...... roles of H3Rs in vivo, we produ......ated with hyperinsulinemia and leptinemia, the funda......ental marks of metabolic syndromes. A s......3R antagonists/inverse agonists ......o regulate feeding and body weight gain in laboratory ani...... that H3Rs are involved in the regulation of feeding behavior and body weight. Se...
- 件名obesity central nervous system disorder inverse agonist
- 参照Diamine Derivatives Containing Imidazolidinylidene Propanedinitrile as a New......Class of Histamine H3 Receptor A......同定と今後の展望 Histamine H3 Receptor A......onists Go to Clinics The Influence of Mast......6 Cervical Carcinoma Cells
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- 内容細目Introduction to s......of sumoylation in mRNA processing and metabolis......UMO and chromatin remodeling / David Wotto......berton, Jacqueline Merrill-Schoo......ctions of SUMO in the maintenance of geno......la Zilio, Karolin Eifler-Olivi, ......Jorrit M. Enserink The molecular interface between......UMO and ubiquitin systems / Jeff L. Staudinger SUMO and nu......nson, Jorge A. Iñiguez-lluhí, ...... roles of SUMO in metabolic regulation / Elena Kamynina, Patrick J. S......e SUMO pathway in mitosis / Deba......ry Dasso Wrestling with chromoso......les of SUMO during meiosis / Ama...... Nottke, Hyun-Min Kim, Monica P. Colaiácovo Su...
- ジャンル・形式用語Fulltext. Internet Resources.
- 件名...fication. Proteins--Synthesis. Ubiquitin. Small Ubiquitin-Related Modifier Proteins--physiology. Biochemical Phe...
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- 要約等...ce for identifying, characterizing, instructing on use, and describing outcomes of neurotoxin treatments – t......ciated with toxin use; to projec......mes of neurotoxin treatments; to gauge neurotoxins as predictors of events leading to neurodegenerative disorders and as aids to......use of neurotoxins to model dise...... is approached in different manners including those 1) affo......tic agents – clinical and preclinical; or 2) by ...... term ‘neurotoxin’ is discussed in terms of the p......otectant producing an outcome of......ysfunction – akin to a neurotoxin’s effect. This......expands on the information provided in the firs...
- 内容細目...ection, and Brain Injury Dopamine D3 receptors ......on Tardive Dyskinesia: Outcome o......eatment and Brain Damage? 6-Hydroxydopamine Neurotoxicity in Adult Animal 6-Hydroxydopamine Neurotoxicity in Perinatal Animals 6-Hydroxydopa in Perinatal and Adult ......echanisms Dopaminergic and Norad......nergic Neurotoxins and Neurodegenerative Disorders anti-NGF Advances in Stem Cell Research for Parkinson's Disease A......thways and Parkinson's Disease R...... Role of VMAT2 in Parkinson's Disease Alpha-Synuclein in Parkinson's Disease Dopaminergic Neurons in Parkinson's Disease Dopamine Oxidation and Parkinson's Disease Neuromelanin and...
- 一般注記Includes index
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- 要約等... entries, covering topics in body systems a......h professions, including nursing, physical therapy, occupatio...
- 内容細目Abdomen Abdominal pain Abdominal ultrasound A......es of daily living evaluation Ac......e Addiction Administration of me......ses Aerobic training/endurance training Aerosol drug administration Affor......ble Care Act Aging and the aged Aging in place AIDS AIDS counseling Air embolism ......lementary medicine Alzheimer's d......bilities Act Amino acid disorders screening Amniocentesis......gy Aneurysm Angina Angiography A......Antepartum testing Anthrax Antia......ical Antiglobulin tests Antihistamines Antihyperten......stance Antiparkinson drugs Antip......iety Apgar testing Aphasia Appen......sound Arterial insufficiency Arterial line Arth...
- 件名Medicine--Encyclopedias Nursing--Encyclopedias Médecine--Encyclopédies Medicine Nursing
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- 要約等Covering everything from historical and international per...... and current clinical practice, ......h Edition, remains the preeminent reference in the field. Dr....... experts who bring you the most up-to-date information avail......entific, and clinical issues you......r you're preparing for the boards, studying for recertifi......ation, or managing a challenging patient care situation in your practice. Contains fully revised......nt throughout, including numerous new videos online. Includes four new chapters: Clinical Care in Extreme Enviro......mplications; Clinical Research; and Interpreting the Medical Literature. Addr...
- 内容細目...armacology and inhaled anesthetics ; Inhaled anestheti......very systems ; Intravenous anest...... ; Nonopioid pain medications ; Intravenous drug ......omuscular blocking drugs ; Rever......atient positioning for anesthesi...... Neuromuscular disorders and other genetic disorders ; Cardiovascular monitoring ; Perioperati......rologic monitoring ; Monitoring depth of anesthesia (monitoring brain state) ; Respiratory monitoring ; Renal patho......nd nephrotoxic injury ; Neuromuscular monitoring ; Airway management in the adult ; Spinal, epidural, a......with chronic pain ; Palliative medicine ; Anesthesia for thoracic su...
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- 要約等Animal Agriculture: Sustainability, Challenges and Innovations discu......h-quality protein by livestock a......important role in improving human nutriti......d marked rises in meat consumpti......al-source protein are expected to increase 72% betw......about the sustainability and env......olution to meeting increasing needs for ani......cts and mitigating undesirable e......nd technology, including biotechnology for the sustainability of anim...... for the expanding global demand of food in the face of diminishing resources. Th......s that gap, giving readers all the necessary information on im......tant issues facing modern animal agriculture, n...
- 内容細目...horne 13. Sustainable sheep and ...... Whitney IV: Swine production: 1......hysiology of swine / Rodney D. G......anagement of swine / William L. ......rition and feeding of swine / Hayford Man......etics and breeding / Giridhar At......f poultry / Colin G. Scanes, Lea......ies and others in animal product...... : challenges, innovations, and sustainability / Steph......ventional breeding to biotechnol......ion techniques in feed productio......hematical modeling in animal production / Luis Orlindo Tedeschi and......nd utilization in production sys......nimal diseases in livestock and ...... Management of metabolic disorders (including metaboli...
- 件名Sustainable agriculture. Livestock--E...
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- 内容細目...ticularly Focusing on Its Contri......erosis Masaaki Inaba 著 Various Kinds of Bone Disease in Diabetes Hitos...... Fracture Risk in Diabetes Masah......f Bone Disease in Diabetes: Abno......azaki, Daisuke Inoue 著 Mechanism......f Bone Disease in Diabetes: Increased Oxidati......f Bone Disease in Diabetes: Rena......alcification Shinsuke Yamada 著 B......ne as an Endocrine Organ: Diabet......Cause of Endocrine Disorder via Osteocalcin, FGF23 Secrete......e Contraction: Intracellular Signaling in Skeletal Muscl......le Contraction in Glucose Homeos......t Accumulation in Muscle Katsuhi......t Accumulation in the Liver and Glucose Homeost...
- 典拠情報（Author Heading/「を見よ」参照）Inaba, Masaaki
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- 内容細目Rare diseases-avoiding misperceptions and establishing realities : t......nce-based medicine and rare dise......aría Luisa Martínez-Frías The im......f case reports in advancing scientific kn......, validity and inference / Rache......a Vehik Biobanking in rare disorders / Hanns Lochmü......of genetic testing for rare dise...... Kalman, and Muin J. Khoury Popu......congenital and inherited disorders : models and c......López-Quílez Clinical trials and......ases / Jordi Llinares Economic considerations in the provision ......be, Richard Edlin, and Jeff Roun...... : analysis of inequalities / An......mic evaluation in rare diseases / Julio López-B...
デジタル電子書籍・電子雑誌図書
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- 要約等... are new, covering topics in body systems a......h professions, including nursing, physical therapy, occupatio...
- 内容細目Abdomen Abdominal pain Abdominal ultrasound A......es of daily living evaluation Ac......Acupuncture Administration of me......ses Aerobic training/endurance training Aerosol drug administration Aging and the aged ......DS AIDS counseling AIDS tests Ai......lementary medicine Alzheimer's d......bilities Act Amino acid disorders screening Amniocentesis......gy Aneurysm Angina Angiography A......Antepartum testing Anthrax Antia......ical Antiglobulin tests Antihistamines Antihyperten...... drugs Antiparkinson drugs Antip......iety Apgar testing Aphasia Appen......sound Arterial insufficiency Arterial line Arthrography Arthroscopy Art...
- 件名Nursing--Encyclopedias. Medicine--Encyclopedias. Medicine. Nursing. Nursing Care. Allied Health Personne...
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- 内容細目... Soroka, Christina Kasper, and Flemming M. Poulsen Ex......acellular protein interactions medi......: heterophilic interactions betw......ar matrix proteins, and viruses ......, Nikolaj Kulahin, and Peter S. Walmod Intracelluar [i.e., Intracellular] li...... of NCAM / Bettina Büttner and R......he role of ATP in the regulation......function / Martin V. Hübschmann and Galina Skladchikova ......ldebrandt, Martina Mühlenhoff, a......le of PSA-NCAM in adult neurogen......se of PSA-NCAM in repair of the ......duction. Signaling pathways involved in NCAM-induced neurite o......ssociated protein GAP-43 in NCAM-mediated neurite outgrow...
- 著者標目Berezin, V. A. (Vladimir Aleksandrovi...
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- 内容細目...gies volume 3. In silico drug di......immunology and inflammation, and infectious diseas......Biologics medicine volume 7. CNS, pain, metabolic syndrome, card......fibrosis and urinary incontinence volume 8. Case histories in recent drug di......REHENSIVE MEDICINAL CHEMISTRY II......REHENSIVE MEDICINAL CHEMISTRY II......EFACE; EDITORS-IN-CHIEF: BIOGRAP......FUTURE OF MEDICINAL CHEMISTRY; Introduction; PER......s: Key Players in the Future of ......Pharmaceutical Industry; 1.01.1 Pharmaceutical Industry Challeng...... Research Coordination Academic ......1.01.2.5 Fully Integrated Academ...... 1.01.3 Concluding Remarks; References; 1.02 Dr...
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- 内容細目...eticulum / Martin Schröder Type ......hew S. Francis Advances in heat shock pro......tter understanding of the physio......ni, Bruno Giardina System specif......yme maturation in bacteria / Ray......ecular biology in molecular imaging / Archana Muk......kur Yeast protein aggregates, containing chaperones an......ns of cyclophilin 40 : a diverge...... loop cyclophilin / Thomas Rataj......t al.] Free-living protists as a......model for studying heat shock proteins in the cell / And......uality control in the secretory ......eat shock protein HspB8 (Hsp22, H11 protein kinase or E2IG1) /......ll stress proteins and their therapeutic potent...
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- 内容細目Contents Vol. 1: Part 1 : Instruments and m......cts Part 1.1 : Instruments used in the assessment......ase impact The international cla......ion of functioning, disability a......easure functioning The Keele ass......rson generated index The total illness burden index The EQ-5D h......versity of Washington quality of......questionnaires in urinary incontinence Overview of instruments used ......uality of life in dentistry SQOR......chronic venous disorders The uniscale a......re The quality in later life que......re The MacDQOL individualized me......ssessment of Chinese general quality of life instrument The Japanese version ...
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- 件名Immunology and Allergy Endocrinology, Diabetes and Metabolism
- 著者標目Stefania Cantore Vito Crincoli Antonio Bo......Michele Fiorentino Giuseppe Monn......ano Andrea Ballini Luigi Santacroce
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- 内容細目...f hypertension in transgenic rat...... and J. J. Mullins Age-related immunological disorders in an animal mode...... / N. Takeichi Increased product......f nitric oxide in cultured aorti......sitive neurons in normal and spo......f central GABA in the regulation......f hypertension in the SHR / M. v...... and acetylcholine microinjected into the nucleus ......Lewis Central kinin receptors in the SHR and th......ponse to bradykinin / C. J. Lindsey Role of muscarinic receptors in cardiovascular regulation in SHR / O. Chung......er Phosphatidylinositol and inositophosphatide metabolism in hypertrophied ...... Nakamura, M. Minami and H. S. Parvez Role of v...
- 件名...athology Rats, Inbred SHR--physi......erebrovascular Disorders--physiopatholo......ypertensie. Bruine ratten.
- 関連情報Progress in hypertension
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- 内容細目...crest cells during ocular morpho......er Transitions in extracellular ......romolecules during avian ocular ......ar development in man / Elise To......zynski The eye in connective tis...... / Gordon K. Klintworth Conjunct......s of lysosomal disorders / Kenneth R. K......choroid and retina / David Valle......iser-Kupfer Retinitis pigmentosa: recent advances / Ronald E. Ca...... Genetic and clinical characteri......lation with retinitis pigmentosa......oughman and Robin J. Caldwell.
- 一般注記...symposium on clinical, structura......nd biochemical advances in hereditary eye disorders.
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