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- 要約等...ses the recent innovations in the developmen......meric systems, including gels, in situ gels, hydrogels, interpenetrating polymer netwo......s. It also examines their applications in drug delivery
- 内容細目1. Biopolymeric gels in drug delivery 2 In situ polymeric......ls for topical drug delivery 3 Interpenetrating polymer networks in sustained drug releasing 4 Polyelectrolyte complexes in sustained drug releasing
- 件名Biopolymers Drug delivery systems Drug Delivery Syste......s Biopolymers. Drug delivery systems.
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- 要約等This book provides understanding of raw materials, manufacturing and biomedica......osites such as drug delivery, grow......and wound dressing
- 内容細目...atural fiber reinforced polymer ......tes: Manufacturing and biomedica......wable and sustainable natural re......ter 4 Soy protein based composit......apter 5 Processing and biomedica......tes: Manufacturing and biomedica......for controlled drug release Chapte......9 Biopolymeric-inorganic composites for drug delivery appli......ancer targeted drug delivery Chapt......or orthopaedic drug delivery in bone tissue engineering Chapter 12 Bi......ite wound dressings Chapter 14 N......nanocomposites in dentistry
- 件名Polymers in medicine Polymères en médecine Polymers in medicine.
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- 要約等...erculosis (TB) in the world, and......result, TB remains the worlds leading infectious cause ......he other hand, in industrialized co......ntries, the TB incidence has fal......ric low, and clinicians experience with TB diminished significantly in recent years. ......allenges for clinicians include atypical ......entation of TB in the immunocomp......lderly, and an increasing number of patients with drug-resistant TB. ......e spread of TB including nosocomial tr......s an air-borne infectious diseas......ent can result in development of drug resistance. Fu......t of latent TB infection (LTBI) ......despite recent innovations in diagnosis and tre...
- 内容細目...nose Latent TB Infection to Prev......B? Chapter 10. Advances in Treatment of Latent TB Infection: What i......reat Latent TB Infection to Prev......ry TB? Part IV Research Areas Chapter 11. TB vaccines: What Type of TB Vaccines are Studied ......l be Available in the Future? Chapter 12. Clinical Trials of ......se Scholars to Advances in Clinical Tuberculosis Management: In TB World, What Kind of Achievemen......ed by Japanese Researchers?
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- 要約等This book provides essential information on recent advances in molecular gene...... translational research, and the latest results of clinical trials on ...... has been made in understanding mesothelioma biology, and in developing new therapies......ize the latest research-based data on ......it also shares insights into future research directions. Th......genesis, screening and early det......enetics, and clinical aspects an...... on new trends in the field, e.g......ar oncogenesis including genetic susce...... immune checkpoint inhibitors, which......paradigm shift in other types of...... MPM patients. In turn, it discusses recent mol...
- 内容細目...y? 11. Circulating tumor cells in malignant pleu...... liquid biopsy in clinical practice o......ics 12. Recent advances on the pathoge......f mesothelioma in genetics and g......What are novel insights into mesothelioma......what are the clinical characteri....... Frequent NF2 inactivation in mesothelioma: ......ons? Part VI Clinical Features a...... 16. Advanced minimally invasive approach...... are the roles in diagnosis? 17. Imaging evaluation of......l tumor growth in malignant pleu......he role of imaging modalities in curative intent surgery fo......ted tomography in malignant pleu......at is the role in mesothelioma detection and tr...
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- 要約等...nanotechnology in medicine and drug delivery, including diagnosis and......rapy. Nanomedicine can contribut......sonalized medicine both for diag......nd therapy. By interacting with biologic......mense field of research and applications. Interactions betw......nderstood both in the extracellular medium and inside human cells. Operating at nanoscale ...... A number of clinical applicatio......arget-specific drug delivery, and molecular imaging are being investigated. Some promising new products ......re also undergoing clinical trials. Su......ion of disease in the future. Th...... is useful for researchers and academicians in the fi...
- 件名Nanomedicine Nanostructured materials Bio...
- タイトル標目Nanotechnology in the life sciences
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- 要約等... have recently increased attention to developing novel drug delivery syste......d exposure can induce mechanical......collapse depending on ultrasound......anical effects induce several bi......gical effects, including enhancement o......meability. For drug delivery, one promising approach is enhancing vascular permeability using ultrasound an......bubbles, resulting in improved drug transport to t......al tissues and drugs to cure disea......c application, including our recent study. We also di...
- 件名blood vessel brain cancer drug delivery microbubble ultrasou...
- 参照...ion by the combination of nanobu......eutic efficacy in a squamous cell carcinoma model Combination of ultras......ct of doxorubicin and inhibit murine osteosarcoma ...... treatment of hindlimb ischemia ...... EAAC1 and its interacting protein GTRAP3-18 Effe......ound-triggered drug delivery Acous......iable carboplatin delivery across the blood-brain barrier with a clinical focused ul......roves survival in a rat glioma m......id bubbles combined with low-intensity ultraso......nd enhance the intratumoral accu......somal doxorubicin <i>in vivo</i> Enhan......ctivity of combined lipid bubble......and anticancer drugs in gynecological cervical ca...
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- 要約等... data projects in Japan. Japan is experiencing unprecedented population aging, and labor pr......ecreased accordingly. Big data a......w readers to gain an understanding of Japanese m......cusses the original Japanese sys......s medical RWDs in the hospital m......public medical insurance system in Japan. After introducing four major bi...... data projects in the healthcaremedical field in Japan, the book explains the importance of creating information standards to maintain data quality a...... standards are installed in which RWDs, ho......tandards are maintained, and which i...... are prevalent in Japan. This book also describ...
- 内容細目...pter 9. Health Information Stand......an Medical Imaging Database (J-M...... 2 : Part 1: Clinical Pathway Ch......Medical Data Clinical Pathway in Japan Chapter ...... analysis by using all-variance ......d electronic clinical pathway da......oratory extracting critical indicator Chapter 3. Information and D......elopment for Clinical Pathways P......ndard Code Mapping and Data Qual......-10 and ICD-11 in Japan Chapter ......es for prescribing drugs use multiple ...... systems depending on their purp......art 3: Phenotyping Chapter 8. Phenotyping in Japan Chapter 9. Phenotyping of Administrative Claim......er 10. Phenotyping study using MID-NET database...
- 件名Epidemiology--Research--Japan Medical informatics--Japan Big data--Jap...
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- 要約等Dopamine plays a central role in the regulation......effect of dopamine is largely me......cAMP/PKA signaling cascade and t...... are expressed in the striatum, ......rofiles of PDE inhibition by selective inhibitors and/or......elated to dopaminergic neurotran......hose PDEs. The inhibition of PDE......cAMP/PKA signaling in three neuronal......ubtypes, resulting in the stimulation of dopamine synthesis at dopaminergic terminals, the inhibition of dopamine D<SUB>2</SUB>......receptor signaling in striatopallida......lation of dopamine D<SUB>1</SUB>......receptor signaling in striatonigral neurons. Predominant roles of PDE families or i...
- 件名cAMP DARPP-32 dopamine phosphorylation striatum
- 参照...ization to cocaine exposure in genetically vu......sphodiesterase Inhibition and Re......lation of Dopaminergic Frontal a......riatal Functioning: Clinical Implicatio......tial for targeting dopamine/DARPP-32 signaling in neuropsychiatr......diesterase 10A in Patients With ......hodiesterase 4 inhibition enhances the dopamine D1 receptor/P......DARPP-32 signaling cascade in frontal cortex
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- 要約等...l Applications in Food, Health a......or development in nanotechnology......uses on overcoming the problems ......dical and food industries. The v......book is broken into three parts ......nanotechnology in food safety"--
- 内容細目...view on Recent Advances, Trends, and B......oemulsions : Principles, Scope, ......d Applications in Transdermal Drug Delivery / Irina Pereira, Sara......l Applications in Agriculture, B......Pharmaceutical Industry : A Revi......olu, and Huey-Min Hwang Nanomate...... Fundamental Principle and Appli......anomaterials : Research and Opportunit...... Encapsulation in Food Systems :......Huma Bader-Ul-Ain, Muhmmad Afzaa......ia Nanosensors in Food Safety : ......ives / Barkha Singhal and Swati Rana.
- 件名... Biotechnology industries. Food industry and trad......logy. Nanomedicine. Pharmaceutical Preparations...
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- 要約等...istry: Applied Research and Interactions prov......kground needed in biophysics and......asizes the growing interrelatedness ......stry, and acquaints one with exp......of both disciplines. This book a......f the enormous advances in biochemistry, particularly in the areas of s......biology and bioinformatics, by providing a solid bioch......that is rooted in chemistry. Topics include scientific integrity and ethics in the field; clinical translational research in cancer, diabet...... disease; emerging drugs to treat neur......ve diseases; swine, avian, and h......se of big data in artificial knowledge in the field; bioinformatic insi...
- 内容細目...tors of checkpoint kinase for cancer ......gonists : emerging drugs to treat neur......ve diseases / Vinod G. Ugale, Ra......B. Bari Recent advances of benzimidazo......e scaffold bearing compounds as ......ymatic targets inhibitors against various fila......ife / Anamika Singh and Rajeev Singh Bioinformatics : pro......challenges / Chin Kang Chen, Her......d Leu Fang-Yie Insights into the natural hypoglycemic principles : translating traditional m......rget knowledge into modern therapy / Satyaendra...
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- 要約等This book tackles the recent research directions in using the newly eme......echnologies during the era of CO......pandemic. It mainly focuses on using emerging technologies ...... also provides insights into the current ......ges and constraints in using technologies during the era of CO......ies for future research in the domain
- 内容細目Intro Preface Lis...... A Survey of Using Machine Learning Algorithms During the COVID-19 ......mic Abstract 1 Introduction 2 COVID-19 Infection Predict......Patients 4 Vaccine Development 5 Drug Discovery 6 Cr......ion and Future Insights References 2 Deep Learning Techniques and COVID-19 Drug Discovery: Fun......irections 2 Bioinformatics and Drug Discovery 3 DL-Based Drug Discovery: Sta......Art 4 COVID-19 Drug Discovery Strategy: A Viewpoint 5 Future Dire......19 Detection Using Advanced CNN ......sed Model Building 5 Results and......6 Conclusion 4 Integration of Deep Learning Machine Models with C......agnostic Tools in Medical Image Analysis for De...
- 件名Technological innovations COVID-19 Pandemic, 2020- Technological innovations.
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- 要約等...e provides the increasing number of SARS-CoV-2 researchers with a usef...... handbook covering multidisciplinary approaches ...... of SARS-CoV-2 research, brought together by leading laboratories ......Topics covered include techniques in clinical and diagno......asic protocols in cell and virus...... as well as bioinformatics and p......ics approaches in cellular respo......covers methods in immunology, an......virals and vaccine development s......for SARS-CoV-2 research. Written for t......essful Methods in Molecular Biol......ries, chapters include the kind of detailed i......al for success in the lab. Practical and timely...
- 内容細目...udy Virus-Host Interactions During SARS-CoV-2 Infection Human N...... by Air-Liquid Interface (ALI) C......ystem for Studying the Pathogene...... Antigens, by Single and Multipl......hemistry Measuring Neutralizing Antibodies to SARS-CoV-2 Using Lentiviral Sp...... Strategies Against SARS-CoV-2: ......for SARS-CoV-2 Infection: Plaque......ct (CPE)-Based Drug Screening Assay for SAR......oV-2 Strengthening Biorisk Management in Research Laboratories w......for SARS-CoV-2 Research in a Biosafety Le...... of SARS-CoV-2 Inactivation
- 件名COVID-19 (Disease)--Research COVID-19 (Disease)
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- 要約等... (Volume 1), Clinical Science (V......cuses on the clinical aspects of autophagy research, discussing the role of autophagy in neuropsychiatr......tive and endocrine systems, as well as tumors, infection, the ki......ophagy-related drug development. W......ts, and presenting the state of the art in autophagy research, this book is ......e resource for researchers and clinicians alike. I...... students majoring in biology and medicine
- 内容細目... /Sheng Chen, Qinming Zhou, You Ni,......ophagy and Parkinson's Disease / Jiahong Lu, Mingyue Wu, and Zh......disease / Zongbing Hao and Guang......c stroke / Yanlin Zhang, Yongjun......c stroke / Yanlin Zhang and Chun...... and polyglutamine disease / Haigang Ren, Zongbing Hao, and Guan......g Ma Autophagy in neurodevelopme......bao Wu and Weiting Gu Autophagy ......iong Yang and Lin Xu part 2. Aut......a / Jie Du, Yulin Di, and Wei Zh...... Yan Liu, and Jintao Fu Autophag...... Yan Liu, and Jintao Fu Autophag......clerosis / Junying Miao, Xiaoling Zang, Xiaoling Cui, and Jun ......n of autophagy in cardiovascular diseases / Jie...
- 並列タイトル等（連結）Clinical science
紙図書
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- 内容細目Recent advances in carbocyclic nu......activity / Jianing Wang, Ravindra K. Rawal, a......n Huang Unraveling of the NAD cyclizing and calcium signaling functions of ......e DNA and RNA binding small molecul......nd its ligands in anticancer the......Molecular modeling in nucleic acid targeted drug design / Lidan...... 10-23 DNAzyme in complex with the target RNA in silico : a pro......opadhyaya Labeling oligonucleoti......ides towards clinical applicatio......l The pharmacokinetics researches of nucleic acid drugs / Shengqi Wang Inducible RNAi and drug target validation / Wei Xiong...
紙図書
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- 要約等...s of tissue engineering as well as the latest advances in the integration of bo......obial and osteoinductive propert......Topics covered include osteocond......ctive and osteoinductive biomate......hogenetic protein, peptides, ant......and scaffolds. Research integrating both antimicrobial/biofilm-inhibiting and osteoinductive/osteoco......nd their roles in clinical success ar......discussed. Combined with its com......ion volume, Racing for the Surfa......imicrobial and Interface Tissue Engineering, this book br......he gap between infection and tissue engineering, and is an id......k for academic researchers, clinicians, industrial en...
- 内容細目... for tissue engineering Carbon nanotu......d applications in bone tissue re......ation Part II: Interface tissue engineering and advanced ......s Fracture healing and progress ......bone tissue engineering and osteoinductive biomaterial research Bioprinting in Tissue Engineering Additive Manufacturing of Bio-scaffo......on Anti-biofouling and Antimicro...... for Tissue Engineering Osteoinductive and ost......tegy for bioengineering Extracellular......Bone Tissue Engineering: Properties and Relevance in Bone Repair Bi......active Glasses in Orthopedic Applications Advances in Tissue Engineering and Regeneration SCAFFOLDS F...
- 件名Tissue engineering. Biological interfaces. Anti-infective agents.
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- 要約等...ndothelium is finely controlled ......ial (VE)-cadherin-mediated endot......ell junctions. In the majority o......othelial cells in blood vessels maintain vascular perme......w level, while in response to inflammation, the......er function to induce plasma lea......ponsible for maintaining homeostasis a...... of its underlying mechanisms result in hyperpermeability, leading to the develo......rious diseases including coronavirus d......, a newly emerging infectious disease. Recently, increasing numbers of st......ave been unveiling the important...... a small guanosine 5′-triphospha......(GTPase) belonging to the Ras superfamily, in t...
- 件名...othelial-cadherin actin cytoskeleton acute lung injury
- 参照Rap1 Is Involved in Angiopoietin-1-Induced Cell-Cell......ial Cell Sprouting Multiple Rap1......ediated tightening of endothelia......ier Disruption Induced by Exotoxins ExoS and ExoT......eudomonas aeruginosa Formin-Mediated Actin Polymerization......ulates E-cadherin-mediated Cell-......e Rap1-RIAM-talin axis of integrin activation and...... Vasculature Clinical course and......oV-2 pneumonia in Wuhan, China: a single-centered, r......tudy Prostacyclin post-treatment improves LPS-induced acute lung injury and endoth......pac1 regulates integrity of endo......rough VE‐cadherin Cdc42 Mediates Bmp-Induced Sprouting Angiogenesis t...
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- 要約等...is regulated mainly by the endot......e cell trafficking. Several molecules are involved in regulating endothelial b...... (Robo4) is a single-pass transmembrane protein that is specif......ally expressed in vascular endot...... role of Robo4 in preventing vascular leak......s been studied in various disease models, including animal models of retinopathy, tumors,......dotoxemia. The involvement of Robo4 in vascular endot......wth factor and inflammation-mediated signaling pathways has ......<i>via</i> distinct mechanisms. In this review, w...... role of Robo4 in endothelial ba......and the underlying molecular mechanisms.</p>
- 参照...factor Robo4 Maintains Vessel Integrity and Inhibits Angiogenesis by Interacting with UNC5B St......nhances ubiquitin-degradation of......tocellular carcinoma progression......polysaccharide-Induced Endothelial Inflammation and ......ysregulated during Endotoxemia R......f ROBO4 Signalling in Developmental ......and Attraction in Roundabout Way......erpermeability in inflammation Structural insights into the Slit-Rob......of Robo4 on Retinal Endothelial ......meability Annexin A2 is a Robo4 ......talk mechanism in inflammation Slit2–Robo4 signalling promotes vasc......bility by blocking Arf6 activity Active involvement of Robo1 and Robo4 i...
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- 要約等<p>Claudin-5 is the dominant tight junction protein in brain endothelial ce......s the blood–brain barrier (BBB).......irment or sustained down-regulat......the passage of drugs across the BBB. While claudin-5 enhancers co......diseases, claudin-5 inhibitors could ......enhance the brain uptake of hydr......lecular-weight drugs. Therefore, t......ffects of claudin-5 manipulation on modulating the BBB in different neur......es further examination. To manipulate claudin-5 expression l......, several claudin-5 modulating molecules hav......een developed. In this review, w......spects of claudin-5 to highlight......anisms of claudin-5 enhancers/inhibitors. We th...
- 件名tight junction blood-brain barrier claudin-5 drug delivery system vascular stab...
- 参照...il on blood–brain barrier integrity The tig...... junction protein occludin modulates blood–brain barrier integrity and neu......schemic stroke in mice Usefulnes......swell blood–brain barrier model ......cal system for drug development ap......ns of blood-brain barrier microphysiological sy...
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- 要約等<p>Liquid biopsy is a minimally invasive test for......sed on circulating tumor DNA (ctDNA), circulating tumor cells, ......ived materials in blood plasma. Although the minimal invasiveness and ......mount of ctDNA in plasma poses p......t developments in digital PCR an......eration sequencing (NGS)-based t......liquid biopsy. In particular, molecular barcoding technology in NGS-based meth......>i.e.</i>, tagging of molecular ......rors by validating the consensus...... sequences originating from a single molecule, leading to marked imp...... mutations originating from normal c......ons on ctDNA. Since there have been only a few ...
- 件名liquid biopsy circulating tumor DNA minimally invasive tumor genotyping molecular barcoding technology ultrarare mutatio...
- 参照Quantitative monitoring of circulating tumor DNA in patients with ...... cancer undergoing chemotherapy